Lange N, Kühnert M, Ebbinghaus F, Hille G, Wolf U
Institut für Pharmakologie, Pharmazie und Toxikologie der Veterinärmedizinischen Fakultät der Universität Leipzig.
Dtsch Tierarztl Wochenschr. 1992 Apr;99(4):145-8.
Investigations were performed to determine the hexobarbital sleeping time (HST) of a strain of Wistar rats (WIST/Lppt). Another aim of the studies was to demonstrate possibilities to use the HST as a method to get additional informations during pharmacological and toxicological experiments. The age--and sex--dependent changes in the hexobarbital sleeping time of the investigated strain of rats are in coincidence with results of other authors, using different rat strains. Additionally, the HST more or less depends on circadian and circannual rhythm. It was stated that the HST as a prescreening-method before starting investigations in detail is of great importance.
进行了多项研究以确定Wistar大鼠品系（WIST/Lppt）的己巴比妥睡眠时间（HST）。这些研究的另一个目的是证明在药理学和毒理学实验中使用HST作为获取更多信息方法的可能性。所研究大鼠品系的己巴比妥睡眠时间随年龄和性别的变化与其他使用不同大鼠品系的作者的结果一致。此外，HST或多或少依赖于昼夜节律和年节律。据指出，在开始详细研究之前，HST作为一种预筛选方法非常重要。
