[半夏根茎化学成分的研究]

[Study on chemical constituents in rhizome of Pinellia ternata].

作者信息

He Ping, Li Shuai, Wang Su-juan, Yang Yong-chun, Shi Jian-gong

机构信息

Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2005 May;30(9):671-4.

PMID:16075730

Abstract

OBJECTIVE

To study the chemical constituents in rhizome of Pinellia ternata.

METHOD

The constituents were isolated by silica-gel and Sephadex LH-20 chromatography. The structures were identified by spectroscopic analysis including 2D NMR techniques.

RESULT

Six compounds were obtained and identified as stigmast-4-en-3-one(I), cycloartenol(II), 5alpha,8alpha-epidioxyergosta-6,22-dien-3-ol(III), beta-sitosterol-3-O-beta-D-glucoside-6'-eicosanate(IV), alpha-monpalmitin(V), beta-sitosterol(VI). The bioactive assay indicated that: compound III was active against the human tumor cell lines HCT-8, Bel-7402, BGC-823, A549, A2780.

CONCLUSION

Compounds I-IV were isolated from Pinellia ternata for the first time, compound II was the first triterpene isolated from this genus. Compound III may be one of the antitumor constituents of P. ternata.

摘要

目的

研究半夏根茎中的化学成分。

方法

采用硅胶柱色谱和葡聚糖凝胶LH - 20柱色谱法分离化合物。通过包括二维核磁共振技术在内的光谱分析鉴定结构。

结果

得到6个化合物，分别鉴定为豆甾-4-烯-3-酮（I）、环阿尔廷醇（II）、5α,8α-环氧麦角甾-6,22-二烯-3-醇（III）、β-谷甾醇-3-O-β-D-葡萄糖苷-6'-二十烷酸酯（IV）、α-单棕榈酸甘油酯（V）、β-谷甾醇（VI）。生物活性测定表明：化合物III对人肿瘤细胞系HCT - 8、Bel - 7402、BGC - 823、A549、A2780具有活性。