Kalra Maninder, Inge Thomas, Garcia Victor, Daniels Stephen, Lawson Louise, Curti Rebecca, Cohen Aliza, Amin Raouf
Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
Obes Res. 2005 Jul;13(7):1175-9. doi: 10.1038/oby.2005.139.
To determine the prevalence of obstructive sleep apnea (OSA) in extremely overweight adolescents and to examine the effect of significant weight loss on OSA severity.
We reviewed the anthropometric and polysomnographic data on all extremely overweight adolescents who underwent laparoscopic Roux en Y gastric bypass surgery at Cincinnati Children's Hospital Medical Center from July 2001 to September 2004. Repeat polysomnograms were performed after significant weight loss. Comparisons were made between pre- and postoperative polysomnographic data.
Nineteen of 34 patients (55%) who underwent bariatric surgery were diagnosed with OSA. Subsequent to surgery, 10 of these patients returned for follow-up polysomnographic testing. After significant weight loss (mean, 58 kg), OSA severity markedly decreased in all patients (median apnea-hypopnea index at baseline vs. after weight loss, 9.1 vs. 0.65).
Our study indicated that OSA was highly prevalent in extremely overweight adolescents meeting eligibility criteria for bariatric surgery. The significant weight loss after gastric bypass was associated with a marked reduction in OSA severity.
确定极度超重青少年中阻塞性睡眠呼吸暂停（OSA）的患病率，并研究显著体重减轻对OSA严重程度的影响。
我们回顾了2001年7月至2004年9月在辛辛那提儿童医院医疗中心接受腹腔镜Roux-en-Y胃旁路手术的所有极度超重青少年的人体测量和多导睡眠图数据。在显著体重减轻后进行了重复多导睡眠图检查。对术前和术后多导睡眠图数据进行了比较。
34例接受减肥手术的患者中有19例（55%）被诊断为OSA。手术后，其中10例患者返回进行多导睡眠图随访检查。在显著体重减轻（平均58千克）后，所有患者的OSA严重程度均显著降低（基线时与体重减轻后的呼吸暂停低通气指数中位数，分别为9.1和0.65）。
我们的研究表明，符合减肥手术资格标准的极度超重青少年中OSA非常普遍。胃旁路手术后的显著体重减轻与OSA严重程度的显著降低相关。
