Lemp G F, Hirozawa A M, Cohen J B, Derish P A, McKinney K C, Hernandez S R
AIDS Office, San Francisco Department of Public Health, CA 94102.
J Infect Dis. 1992 Jul;166(1):74-9. doi: 10.1093/infdis/166.1.74.
To compare trends in the length of survival for women and men after diagnosis of AIDS, data were analyzed for 139 women and 7045 men who were reported with AIDS in San Francisco between July 1981 and 31 December 1990. Patients were followed prospectively through 15 May 1991. The median survival for women (11.1 months) was significantly shorter than that for men (14.6 months). When data were stratified by year of diagnosis, significantly improved survival was observed in recent years for both women and men, although survival for women remained significantly shorter than that for men. Among those who received either zidovudine or 2',3'-dideoxyinosine, survival did not differ by gender. However, among those not receiving therapy, survival was significantly shorter for women. These results suggest that the shorter survival of women may be a result of factors other than gender, possibly including less use of antiretroviral therapy.
为比较艾滋病确诊后女性和男性的生存时长趋势,对1981年7月至1990年12月31日期间旧金山报告的139名女性和7045名男性艾滋病患者的数据进行了分析。对患者进行前瞻性随访至1991年5月15日。女性的中位生存期(11.1个月)显著短于男性(14.6个月)。按诊断年份分层数据时,近年来女性和男性的生存期均有显著改善,尽管女性的生存期仍显著短于男性。在接受齐多夫定或2',3'-双脱氧肌苷治疗的患者中,生存期无性别差异。然而,在未接受治疗的患者中,女性的生存期显著较短。这些结果表明,女性生存期较短可能是由性别以外的因素导致的,可能包括抗逆转录病毒疗法的使用较少。