Vasconcelos Ana Tereza R, Ferreira Henrique B, Bizarro Cristiano V, Bonatto Sandro L, Carvalho Marcos O, Pinto Paulo M, Almeida Darcy F, Almeida Luiz G P, Almeida Rosana, Alves-Filho Leonardo, Assunção Enedina N, Azevedo Vasco A C, Bogo Maurício R, Brigido Marcelo M, Brocchi Marcelo, Burity Helio A, Camargo Anamaria A, Camargo Sandro S, Carepo Marta S, Carraro Dirce M, de Mattos Cascardo Júlio C, Castro Luiza A, Cavalcanti Gisele, Chemale Gustavo, Collevatti Rosane G, Cunha Cristina W, Dallagiovanna Bruno, Dambrós Bibiana P, Dellagostin Odir A, Falcão Clarissa, Fantinatti-Garboggini Fabiana, Felipe Maria S S, Fiorentin Laurimar, Franco Gloria R, Freitas Nara S A, Frías Diego, Grangeiro Thalles B, Grisard Edmundo C, Guimarães Claudia T, Hungria Mariangela, Jardim Sílvia N, Krieger Marco A, Laurino Jomar P, Lima Lucymara F A, Lopes Maryellen I, Loreto Elgion L S, Madeira Humberto M F, Manfio Gilson P, Maranhão Andrea Q, Martinkovics Christyanne T, Medeiros Sílvia R B, Moreira Miguel A M, Neiva Márcia, Ramalho-Neto Cicero E, Nicolás Marisa F, Oliveira Sergio C, Paixão Roger F C, Pedrosa Fábio O, Pena Sérgio D J, Pereira Maristela, Pereira-Ferrari Lilian, Piffer Itamar, Pinto Luciano S, Potrich Deise P, Salim Anna C M, Santos Fabrício R, Schmitt Renata, Schneider Maria P C, Schrank Augusto, Schrank Irene S, Schuck Adriana F, Seuanez Hector N, Silva Denise W, Silva Rosane, Silva Sérgio C, Soares Célia M A, Souza Kelly R L, Souza Rangel C, Staats Charley C, Steffens Maria B R, Teixeira Santuza M R, Urmenyi Turan P, Vainstein Marilene H, Zuccherato Luciana W, Simpson Andrew J G, Zaha Arnaldo
Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Avenida Bento Gonçalves 9500, Prédio 43421, Porto Alegre, RS, Brazil.
J Bacteriol. 2005 Aug;187(16):5568-77. doi: 10.1128/JB.187.16.5568-5577.2005.
This work reports the results of analyses of three complete mycoplasma genomes, a pathogenic (7448) and a nonpathogenic (J) strain of the swine pathogen Mycoplasma hyopneumoniae and a strain of the avian pathogen Mycoplasma synoviae; the genome sizes of the three strains were 920,079 bp, 897,405 bp, and 799,476 bp, respectively. These genomes were compared with other sequenced mycoplasma genomes reported in the literature to examine several aspects of mycoplasma evolution. Strain-specific regions, including integrative and conjugal elements, and genome rearrangements and alterations in adhesin sequences were observed in the M. hyopneumoniae strains, and all of these were potentially related to pathogenicity. Genomic comparisons revealed that reduction in genome size implied loss of redundant metabolic pathways, with maintenance of alternative routes in different species. Horizontal gene transfer was consistently observed between M. synoviae and Mycoplasma gallisepticum. Our analyses indicated a likely transfer event of hemagglutinin-coding DNA sequences from M. gallisepticum to M. synoviae.
本研究报告了对三种支原体完整基因组的分析结果，这三种支原体分别是猪肺炎支原体的致病菌株（7448）和非致病菌株（J）以及鸡滑液囊支原体的一个菌株；这三个菌株的基因组大小分别为920,079 bp、897,405 bp和799,476 bp。将这些基因组与文献中报道的其他已测序支原体基因组进行比较，以研究支原体进化的几个方面。在猪肺炎支原体菌株中观察到了菌株特异性区域，包括整合和接合元件，以及基因组重排和黏附素序列的改变，所有这些都可能与致病性有关。基因组比较显示，基因组大小的减小意味着冗余代谢途径的丧失，不同物种中维持了替代途径。在鸡滑液囊支原体和鸡毒支原体之间持续观察到水平基因转移。我们的分析表明，血凝素编码DNA序列可能从鸡毒支原体转移到了鸡滑液囊支原体。
