Plourde P J, Plummer F A, Pepin J, Agoki E, Moss G, Ombette J, Ronald A R, Cheang M, D'Costa L, Ndinya-Achola J O
Department of Medical Microbiology, University of Nairobi, Kenya.
J Infect Dis. 1992 Jul;166(1):86-92. doi: 10.1093/infdis/166.1.86.
A cross-sectional study was conducted among women attending a sexually transmitted diseases clinic in Nairobi, kenya, to determine the prevalence of and associated risk factors for human immunodeficiency virus (HIV) type 1 infection. HIV-1 antibody was detected in 13.8% of 600 women. This virus was found most frequently in prostitutes (odds ratio [OR], 7.2), in women reporting a history of genital ulcers (OR, 2.3), and in those with a current diagnosis of genital ulcers (OR, 5.1). Lifetime duration of oral contraceptive use was significantly greater in HIV-1-positive women. Multivariate analysis revealed an association between genital ulcers and HIV-1 infection (OR, 3.8). The strongest association for HIV-1 infection, however, occurred with genital ulcers in combination with the use of oral contraceptives (OR, 25.7).
在肯尼亚内罗毕一家性传播疾病诊所就诊的女性中开展了一项横断面研究,以确定1型人类免疫缺陷病毒(HIV)感染的患病率及其相关危险因素。在600名女性中,13.8%检测出HIV-1抗体。该病毒在妓女中最为常见(比值比[OR]为7.2),有生殖器溃疡病史的女性中也较为常见(OR为2.3),以及目前诊断为生殖器溃疡的女性中(OR为5.1)。HIV-1阳性女性使用口服避孕药的终生时长显著更长。多变量分析显示生殖器溃疡与HIV-1感染之间存在关联(OR为3.8)。然而,HIV-1感染的最强关联发生在生殖器溃疡与口服避孕药联合使用的情况下(OR为25.7)。