Krichmar Jeffrey L, Seth Anil K, Nitz Douglas A, Fleischer Jason G, Edelman Gerald M
The Neurosciences Institute, 10640 John J. Hopkins Drive, San Diego, CA 92121, USA.
Neuroinformatics. 2005;3(3):197-221. doi: 10.1385/NI:3:3:197.
We describe Darwin X, a physical device that interacts with a real environment, whose behavior is guided by a simulated nervous system incorporating aspects of the detailed anatomy and physiology of the hippocampus and its surrounding regions. This brain-based device integrates cues from its environment and solves a spatial memory task. The responses of simulated neuronal units in the hippocampal areas during its exploratory behavior are comparable to place cells in the rodent hippocampus and emerged by associating sensory cues during exploration. To identify different functional hippocampal pathways and their influence on behavior, we employed a time series analysis that distinguishes causal interactions within and between simulated hippocampal and neocortical regions while the device is engaged in a spatial memory task. Our analysis identified different functional pathways within the neural simulation and prompts novel predictions about the influence of the perforant path, the trisynaptic loop and hippocampal-cortical interactions on place cell activity and behavior during navigation. Moreover, this causal time series analysis may be useful in analyzing networks in general.
我们描述了达尔文X，这是一种与真实环境相互作用的物理设备，其行为由一个模拟神经系统引导，该系统融合了海马体及其周围区域详细的解剖学和生理学特征。这种基于大脑的设备整合来自其环境的线索并解决空间记忆任务。在其探索行为期间，海马区模拟神经元单元的反应与啮齿动物海马体中的位置细胞相当，并且是通过在探索过程中关联感觉线索而出现的。为了识别不同的功能性海马通路及其对行为的影响，我们采用了时间序列分析，该分析在设备执行空间记忆任务时区分模拟海马体和新皮质区域内部以及之间的因果相互作用。我们的分析确定了神经模拟中的不同功能通路，并对穿通通路、三突触回路和海马-皮质相互作用在导航过程中对位置细胞活动和行为的影响提出了新的预测。此外，这种因果时间序列分析可能总体上对分析网络有用。
