Matteucci A, Frank C, Domenici M R, Balduzzi M, Paradisi S, Carnovale-Scalzo G, Scorcia G, Malchiodi-Albedi F
Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, Italy.
Exp Brain Res. 2005 Dec;167(4):641-8. doi: 10.1007/s00221-005-0068-0. Epub 2005 Aug 3.
Curcumin, an extract from the plant Curcuma longa with well-known antioxidant and anti-inflammatory activities, was tested as protective agent against excitotoxicity in rat retinal cultures. A 24 h-treatment with curcumin reduced N-methyl-D: -aspartate (NMDA)-mediated excitotoxic cell damage, estimated as decrease of cell viability and increase in apoptosis. The protection was associated with decrease of NMDA receptor-mediated Ca(2+) rise and reduction in the level of phosphorylated NR1 subunit of the NMDA receptor. These results enlighten a new pharmacological action of the plant extract, possibly mediated by a modulation of NMDA receptor activity.
姜黄素是从植物姜黄中提取的一种具有著名抗氧化和抗炎活性的物质，它作为一种保护剂，在大鼠视网膜培养物中被测试用于抵抗兴奋毒性。用姜黄素进行24小时处理可减少N-甲基-D-天冬氨酸（NMDA）介导的兴奋毒性细胞损伤，这可通过细胞活力的降低和细胞凋亡的增加来估计。这种保护作用与NMDA受体介导的钙离子升高的降低以及NMDA受体磷酸化NR1亚基水平的降低有关。这些结果揭示了这种植物提取物的一种新的药理作用，可能是通过对NMDA受体活性的调节来介导的。
