Han Quan-Bin, Lee Song-Fong, Qiao Chun-Feng, He Zhen-Dan, Song Jing-Zheng, Sun Han-Dong, Xu Hong-Xi
Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, PR China.
Chem Pharm Bull (Tokyo). 2005 Aug;53(8):1034-6. doi: 10.1248/cpb.53.1034.
From the antibacterial fraction of the roots of Garcinia kola, 3'',4',4''',5,5'',7,7''-heptahydroxy-3,8''-biflavanone (GB1) was isolated as the major constituent, whose interesting conformations were studied on the basis of its 1D and 2D NMR spectra obtained at different temperatures and in different solvents. GB1 showed antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) with MIC of 32 and 128 microg/ml, respectively.
从可乐果根的抗菌提取物中，分离得到了主要成分3'',4',4''',5,5'',7,7''-七羟基-3,8''-双黄酮（GB1），并根据其在不同温度和不同溶剂中获得的一维和二维核磁共振谱对其有趣的构象进行了研究。GB1对耐甲氧西林金黄色葡萄球菌（MRSA）和耐万古霉素肠球菌（VRE）显示出抗菌活性，其最低抑菌浓度分别为32和128微克/毫升。
