Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong SAR, PR China.
Chin Med. 2008 Jun 28;3:7. doi: 10.1186/1749-8546-3-7.
Selection of chemical markers is crucial for the quality control of herbal medicines, including authentication of genuine species, harvesting the best quality raw materials, evaluation of post-harvesting handling, assessment of intermediates and finished products, and detection of harmful or toxic ingredients. Ideal chemical markers should be the therapeutic components of herbal medicines. However, for most herbal medicines, the therapeutic components have not been fully elucidated or easily monitored. Bioactive, characteristic, main, synergistic, correlative, toxic and general components may be selected. This article reviews the effective use of chemical markers in the quality control of herbal medicines including the selection criteria considering the roles and physicochemical factors which may affect the effective use of chemical markers.
化学标志物的选择对于草药的质量控制至关重要，包括鉴定正品物种、收获最佳质量的原材料、评估收获后的处理、评估中间体和成品，以及检测有害或有毒成分。理想的化学标志物应该是草药的治疗成分。然而，对于大多数草药来说，治疗成分尚未完全阐明或难以监测。可以选择生物活性、特征、主要、协同、相关、毒性和一般成分。本文综述了化学标志物在草药质量控制中的有效应用，包括考虑到可能影响化学标志物有效使用的作用和理化因素的选择标准。
