Pomilio A B, Buschi C A, Tomes C N, Viale A A
Departamento de Quimica Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
J Ethnopharmacol. 1992 Apr;36(2):155-61. doi: 10.1016/0378-8741(92)90016-k.
The antimicrobial activity of extracts and constituents of Gomphrena martiana and Gomphrena boliviana (Amaranthaceae) were determined in order to identify the compounds responsible for the folk-medicinal use of these plants. Each extract was evaluated against 20 microorganisms, including Gram-positive and Gram-negative bacteria, spore-forming Gram-positive bacteria, an acid-fast bacterium, a fungus and two yeasts. Fractionation of each petroleum ether (PE) extract yielded five 5,6,7-trisubstituted flavones that were separately tested showing high activity against M. phlei (minimum inhibitory concentration (MIC) 15, 20 and 75 micrograms/ml) approaching that of commercial bactericides. Other natural and synthetic flavonoids with diverse structures were also tested to define structure-activity relationships. Each EtOH extract was subsequently fractionated and monitored by bioassays leading to isorhamnetin 3-O-beta-robinobioside (MIC 50 micrograms/ml) in both instances. This glycoside is reported here for the first time in G. boliviana.
测定了马丁千日红和玻利维亚千日红（苋科）提取物及其成分的抗菌活性，以鉴定这些植物在民间医学应用中的有效成分。每种提取物针对20种微生物进行了评估，包括革兰氏阳性菌和革兰氏阴性菌、产芽孢革兰氏阳性菌、抗酸菌、一种真菌和两种酵母。每种石油醚（PE）提取物经分馏得到5种5,6,7-三取代黄酮，分别进行测试，结果显示其对草分枝杆菌具有高活性（最低抑菌浓度（MIC）为15、20和75微克/毫升），接近市售杀菌剂的活性。还测试了其他具有不同结构的天然和合成类黄酮，以确定构效关系。随后对每种乙醇提取物进行分馏，并通过生物测定法进行监测，在两种情况下均得到异鼠李素3-O-β-刺槐二糖苷（MIC为50微克/毫升）。该糖苷首次在玻利维亚千日红中报道。
