从千日红（Gomphrena celosioides C. Mart.）中分离出橙酰胺类化合物
Isolation of aurantiamides from gomphrena celosioides C. Mart.
作者信息
Olutola Dosumu Omotayo, Onocha Patricia, Ekundayo Olusegun, Ali Muhammad
机构信息
Department of Chemistry, University of Ilorin, Ilorin.
Department of Chemistry, University of Ibadan, Ibadan.
出版信息
Iran J Pharm Res. 2014 Winter;13(1):143-7.
In West Africa and Nigeria in particular, many virgin plants are still waiting to be evaluated for their medicinal importance. Claims of plants with folk medicinal applications need to be evaluated and verified. Gomphrena celosioides (family - Amaranthaceae) is a weed grown in lawns and the biological activity of the extract had earlier been established. In the present study, the plant was collected, air dried, ground and soxhlet extracted with n-hexane and two compounds were isolated from the flakes that were recovered from the n-hexane extract on cooling. Column chromatography using 5% chloroform in n-hexane effected the separation. The structures of the isolated compounds were elucidated by spectroscopic analysis using IR, NMR ((1)H and (13)C) and EI-MS. The compounds were found to be aurantiamide and aurantiamide acetate. This is the first report of isolation of these compounds in Gomphrena celosioides.
在西非，尤其是尼日利亚，许多原生植物仍有待评估其药用价值。具有民间药用用途的植物声称需要进行评估和验证。千日红（苋科）是一种生长在草坪上的杂草，其提取物的生物活性此前已得到证实。在本研究中，采集该植物，风干、研磨，并用正己烷进行索氏提取，从冷却后正己烷提取物中回收的薄片中分离出两种化合物。使用5%氯仿的正己烷溶液进行柱色谱分离。通过红外光谱、核磁共振（氢谱和碳谱）和电子轰击质谱等光谱分析确定了分离出的化合物的结构。这些化合物被发现是橙酰胺和橙酰胺乙酸酯。这是首次在千日红中分离出这些化合物的报道。
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