Isolation of 3-(4-hydroxyphenyl) methylpropenoate and bioactivity evaluation of Gomphrena celosioides extracts.

The efficacy of extracts in traditional medicine in the treatment of infectious diseases was evaluated by biological assays. The bioactivities of the extracts of this plant were tested against organisms. The ethyl acetate and methanol extracts of the plant displayed inhibition activities on and . Methanol extract was active against s, and with diameter zones of inhibition between 14 and 20 mm. Fractionation of the methanol extract produced 3-(4-hydroxyphenyl) methylpropenoate with mild antimicrobial activity against the test microorganisms. The anthelmintic assay showed ethyl acetate and methanol extracts to be active against and . Ethyl acetate was the most toxic of the extracts causing paralysis of within 15 minutes and the death of within 20 minutes of application. The brine shrimp assay gave an LC of 52.15 and 77.98 µg/ml on hexane and methanol extracts respectively. The result of this work corroborated the folkloric use of in the treatment of infectious diseases.