Chotmongkol Verajit, Limpawattana Panita
Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
J Med Assoc Thai. 2005 Jun;88(6):855-8.
A case of Wernicke's encephalopathy is reported. A 53-year-old alcoholic man was presented with acute confusion, upward gaze palsy of the left eye and gait ataxia for 5 days. The typical findings upon MRI of the brain showed multiple, scattered, small non-enhanced low signal intensity on T1WI, high signal intensity on T2WI involving at bilateral basal ganglias, and thalami, midbrain, pons, and periventricular regions with evidence of atrophic changes of brain and the mamillary bodies. After treatment with intravenous thiamine 100 mg/day, the left upward gaze palsy was fully recovered at the 8th day of treatment. The mental status and gait ataxia gradually improved.
报告了一例韦尼克脑病病例。一名53岁的男性酗酒者出现急性意识模糊、左眼向上凝视麻痹和步态共济失调5天。脑部MRI的典型表现为：在T1加权像上有多个散在的小的无强化低信号灶，在T2加权像上为高信号，累及双侧基底节、丘脑、中脑、脑桥和脑室周围区域，并有脑萎缩和乳头体萎缩的证据。经静脉注射硫胺素100毫克/天治疗后，治疗第8天左眼向上凝视麻痹完全恢复。精神状态和步态共济失调逐渐改善。
