Acconcia Filippo, Kumar Rakesh
Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.
Cancer Lett. 2006 Jul 8;238(1):1-14. doi: 10.1016/j.canlet.2005.06.018. Epub 2005 Aug 3.
Estrogen receptors (ERs) mediate the effects of 17beta-estradiol under physiologic and pathologic conditions. ERs trigger 17beta-estradiol-sensitive gene transcription by binding to specific estrogen response elements (i.e. genomic mechanism). The cellular effects of estrogen are also influenced by membrane- or cytoplasm-initiated responses (i.e. nongenomic mechanism). Both ER-evoked genomic and nongenomic effects originate from a unique signaling network. Furthermore, estrogen-initiated rapid pathways and ERalpha interactions with specific partners (e.g. AIB1, PELP1/MNAR; MTA1, MTA1s and p130Cas) influence both ER functions. Here, we summarize the recent findings related to multiple regulatory levels of the signaling networks responsible for ERs-mediated responses in breast cancer cells.
雌激素受体（ERs）在生理和病理条件下介导17β-雌二醇的作用。ERs通过与特定的雌激素反应元件结合来触发17β-雌二醇敏感基因转录（即基因组机制）。雌激素的细胞效应也受膜或细胞质起始反应的影响（即非基因组机制）。ER引发的基因组和非基因组效应均源自独特的信号网络。此外，雌激素起始的快速通路以及ERα与特定伴侣（如AIB1、PELP1/MNAR；MTA1、MTA1s和p130Cas）的相互作用会影响ER的功能。在此，我们总结了与负责乳腺癌细胞中ER介导反应的信号网络多个调控水平相关的最新研究发现。
