• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Human gene therapy comes of age.

作者信息

Miller A D

机构信息

Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.

出版信息

Nature. 1992 Jun 11;357(6378):455-60. doi: 10.1038/357455a0.

DOI:10.1038/357455a0
PMID:1608446
Abstract

Advances in the understanding of molecular biology of human disease and the development of efficient gene transfer techniques have resulted in practical approaches to human gene therapy, with new techniques being developed at an increasing rate. The first trials have now begun in humans and initial results are positive.

摘要

相似文献

1
Human gene therapy comes of age.
Nature. 1992 Jun 11;357(6378):455-60. doi: 10.1038/357455a0.
2
Targeted gene modification for gene therapy of stem cells.用于干细胞基因治疗的靶向基因修饰
Int J Cell Cloning. 1990 Mar;8(2):80-96. doi: 10.1002/stem.5530080202.
3
Fetal gene therapy: opportunities and risks.胎儿基因治疗：机遇与风险。
Adv Drug Deliv Rev. 2009 Aug 10;61(10):813-21. doi: 10.1016/j.addr.2009.04.011. Epub 2009 May 6.
4
Human somatic cell gene therapy.人类体细胞基因治疗。
Bioessays. 1996 Dec;18(12):999-1007. doi: 10.1002/bies.950181210.
5
Gene transfer and the prospects for somatic gene therapy.基因转移与体细胞基因治疗的前景。
Hematol Oncol Clin North Am. 1988 Jun;2(2):277-87.
6
[The advances of gene therapy in this quarter century].[这四分之一个世纪里基因治疗的进展]
Gan To Kagaku Ryoho. 1999 Jun;26 Suppl 1:51-9.
7
[Prospects for gene therapy in hematology].[血液学中基因治疗的前景]
Ann Biol Clin (Paris). 1999 Jan-Feb;57(1):43-50.
8
Cellular gene therapy.细胞基因治疗
Hematol Oncol Clin North Am. 1995 Feb;9(1):91-113.
9
[Viral vectors for clinical gene therapy].[用于临床基因治疗的病毒载体]
Ugeskr Laeger. 2002 Sep 9;164(37):4272-6.
10
Gene therapy in perspective.
Nature. 1991 Jan 24;349(6307):275-6. doi: 10.1038/349275a0.

引用本文的文献

1
A novel multi-functional chimeric peptide for enhanced safe gene delivery in immunotherapy.一种用于免疫治疗中增强安全基因递送的新型多功能嵌合肽。
Gene Ther. 2025 Apr 30. doi: 10.1038/s41434-025-00538-5.
2
Lipid-nanoparticle-enabled nucleic acid therapeutics for liver disorders.用于肝脏疾病的脂质纳米颗粒核酸疗法。
Acta Pharm Sin B. 2024 Jul;14(7):2885-2900. doi: 10.1016/j.apsb.2024.04.015. Epub 2024 Apr 22.
3
RNA-Based Vaccines and Therapeutics Against Intracellular Pathogens.基于 RNA 的疫苗和针对细胞内病原体的治疗方法。
Methods Mol Biol. 2024;2813:321-370. doi: 10.1007/978-1-0716-3890-3_21.
4
Advanced genetic therapies for the treatment of Rett syndrome: state of the art and future perspectives.用于治疗雷特综合征的先进基因疗法：现状与未来展望。
Front Neurosci. 2023 May 25;17:1172805. doi: 10.3389/fnins.2023.1172805. eCollection 2023.
5
Adenovirus vector-mediated single chain variable fragments target the nucleocapsid protein of porcine epidemic diarrhea virus and protect against viral infection in piglets.腺病毒载体介导的单链可变片段靶向猪流行性腹泻病毒的核衣壳蛋白并保护仔猪免受病毒感染。
Front Immunol. 2023 Jan 24;14:1058327. doi: 10.3389/fimmu.2023.1058327. eCollection 2023.
6
Understanding the research advances on lumpy skin disease: A comprehensive literature review of experimental evidence.了解牛结节性皮肤病的研究进展：实验证据的综合文献综述
Front Microbiol. 2022 Nov 28;13:1065894. doi: 10.3389/fmicb.2022.1065894. eCollection 2022.
7
Editorial: Hair cells: From molecules to function, volume II.社论：毛细胞：从分子到功能，第二卷。
Front Cell Neurosci. 2022 Oct 13;16:1046646. doi: 10.3389/fncel.2022.1046646. eCollection 2022.
8
Advancing precision medicines for ocular disorders: Diagnostic genomics to tailored therapies.推进针对眼部疾病的精准药物：从诊断基因组学到个性化疗法。
Front Med (Lausanne). 2022 Jul 15;9:906482. doi: 10.3389/fmed.2022.906482. eCollection 2022.
9
Gene-Based Therapeutics for Inherited Retinal Diseases.用于遗传性视网膜疾病的基因疗法
Front Genet. 2022 Jan 7;12:794805. doi: 10.3389/fgene.2021.794805. eCollection 2021.
10
Induced Pluripotent Stem Cells (iPSCs) and Gene Therapy: A New Era for the Treatment of Neurological Diseases.诱导多能干细胞 (iPSCs) 和基因治疗：治疗神经疾病的新时代。
Int J Mol Sci. 2021 Dec 20;22(24):13674. doi: 10.3390/ijms222413674.