Frauscher Birgit, Egg Robert, Brandauer Elisabeth, Ulmer Hanno, Berger Thomas, Poewe Werner, Högl Birgit
Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria.
Sleep Med. 2005 Nov;6(6):543-7. doi: 10.1016/j.sleep.2005.05.001. Epub 2005 Aug 5.
Daytime sleepiness has been described in multiple sclerosis (MS); a combination of MS and narcolepsy has also been observed in a few case reports. In this study, we investigated daytime sleepiness in a general sample of MS patients compared to healthy controls with the pupillographic sleepiness test (PST) and the Epworth and Stanford sleepiness scales (ESS, SSS).
A PST was performed in consecutive MS patients and controls. Additionally, a questionnaire including the ESS and the SSS was applied.
Sixty-one MS patients (29 men and 32 women, age 34.5+/-8.3 years, mean disease duration 7.4+/-6.6 years, expanded disability status scale (EDSS) 1.7+/-1.2 (mean +/- sd)) and 42 age-matched controls (13 men and 29 women, age 36.9+/-12.9 years) participated in this study. In the MS group, the pupillary unrest index (PUI) was 5.0+/-2.0, the ESS 7.4+/-3.5 and the SSS 2.4+/-1.2, whereas in the control group, the PUI was 4.7+/-1.8, the ESS 8.4+/-4.0 and the SSS 2.4+/-1.2 (mean +/- sd). These differences were not significant. No correlation was found between PUI and the ESS or the SSS. Furthermore, no correlation was found between EDSS and sleepiness measured by PUI, ESS and SSS.
In a general sample of MS patients with mild to moderate disease, there was no evidence for overall increased daytime sleepiness compared to healthy controls.
多发性硬化症（MS）患者中存在日间嗜睡现象；少数病例报告中也观察到MS与发作性睡病并存的情况。在本研究中，我们通过瞳孔描记法嗜睡测试（PST）、埃普沃思嗜睡量表（ESS）和斯坦福嗜睡量表（SSS），对MS患者的一般样本与健康对照者的日间嗜睡情况进行了调查。
对连续的MS患者和对照者进行PST测试。此外，应用了包含ESS和SSS的问卷。
61例MS患者（29例男性和32例女性，年龄34.5±8.3岁，平均病程7.4±6.6年，扩展残疾状态量表（EDSS）1.7±1.2（均值±标准差））和42例年龄匹配的对照者（13例男性和29例女性，年龄36.9±12.9岁）参与了本研究。MS组的瞳孔不安指数（PUI）为5.0±2.0，ESS为7.4±3.5，SSS为2.4±1.2；而对照组的PUI为4.7±1.8，ESS为8.4±4.0，SSS为2.4±1.2（均值±标准差）。这些差异无统计学意义。未发现PUI与ESS或SSS之间存在相关性。此外，EDSS与通过PUI、ESS和SSS测量的嗜睡程度之间也未发现相关性。
在疾病程度为轻度至中度的MS患者一般样本中，与健康对照者相比，没有证据表明总体日间嗜睡增加。
