Emory University School of Medicine, Department of Neurology, Atlanta, GA 30329, USA.
Parkinsonism Relat Disord. 2009 Dec;15(10):784-6. doi: 10.1016/j.parkreldis.2009.04.007. Epub 2009 May 15.
Few investigations have examined sleep in cervical dystonia (CD) patients. We assessed 43 consecutive CD patients, 19 patients with other focal movement disorders, and 49 healthy, age- and gender-matched controls for the presence of excessive daytime sleepiness (as measured by the Epworth Sleepiness Scale, ESS). All patients were receiving botulinum toxin. We found that a higher percentage of CD patients had abnormal ESS scores of >11 than did either of the two control groups (21% vs. 0% vs. 4%, p < 0.05 for each pairwise comparison with the CD group). Use of anticholinergic medications accounted for some but not all of this increase in sleepiness in the CD group. Age, gender, race, scores on the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) or its subscores (severity, disability, and pain), and other common medication use (benzodiazepines, antidepressants) were not associated with increased ESS scores. This preliminary finding of excessive daytime sleepiness in a substantial portion of CD patients suggests that further investigation into disordered sleep in CD is warranted.
鲜有研究调查过颈肌张力障碍（CD）患者的睡眠情况。我们评估了 43 例连续的 CD 患者、19 例其他局灶性运动障碍患者和 49 名年龄和性别匹配的健康对照者，以评估日间过度嗜睡（通过 Epworth 嗜睡量表，ESS）的存在情况。所有患者均接受肉毒毒素治疗。我们发现，与两个对照组相比，更多的 CD 患者 ESS 评分异常（>11）（21%比 0%比 4%，与 CD 组的每项两两比较均 p<0.05）。使用抗胆碱能药物可以解释 CD 组嗜睡增加的部分原因，但不是全部原因。年龄、性别、种族、多伦多西部痉挛性斜颈严重程度评分量表（TWSTRS）或其亚评分（严重程度、残疾和疼痛）、以及其他常见药物使用（苯二氮䓬类、抗抑郁药）与 ESS 评分增加无关。这一初步发现表明，相当一部分 CD 患者存在日间过度嗜睡，这表明进一步研究 CD 患者的睡眠障碍是合理的。
