甲状腺乳头状癌滤泡变体的一个亚群存在PAX8-PPARγ易位。

A subset of the follicular variant of papillary thyroid carcinoma harbors the PAX8-PPARgamma translocation.

作者信息

Castro Patrícia, Roque Lúcia, Magalhães João, Sobrinho-Simões Manuel

机构信息

IPATIMUP, Institute of Pathology Molecular and Immunology of the University of Porto, Portugal.

出版信息

Int J Surg Pathol. 2005 Jul;13(3):235-8. doi: 10.1177/106689690501300301.

DOI:10.1177/106689690501300301

PMID:16086077

Abstract

The occurrence of the PAX8-PPARgamma fusion gene is thought to be restricted to follicular tumors (adenomas and carcinomas) of the thyroid (FTA and FTC). Using interphase fluorescent in situ hybridization (FISH), together with recombinant tissue-type polymerase chain reaction (RT-PCR) and immunohistochemistry, we detected the PAX8-PPARgamma translocation in 4 of 8 cases of the follicular variant of papillary thyroid carcinoma (FVPTC) exclusively or almost exclusively (>95%) composed of follicles. The 4 tumors with the translocation were larger and apparently more invasive than the remaining tumors, but the series is too small to allow a statistically meaningful comparison of the data. Our findings show that follicular thyroid carcinoma (PTC) may also harbor the PAX8-PPARgamma fusion gene and indicate that a subset of FVPTC shares some molecular features of FTA and FTC.

摘要

PAX8-PPARγ融合基因的出现被认为仅限于甲状腺滤泡性肿瘤（腺瘤和癌）（FTA和FTC）。我们使用间期荧光原位杂交（FISH），结合重组组织型聚合酶链反应（RT-PCR）和免疫组织化学，在8例主要或几乎完全（>95%）由滤泡构成的甲状腺乳头状癌滤泡变体（FVPTC）中，检测到4例存在PAX8-PPARγ易位。发生易位的这4个肿瘤比其余肿瘤更大，且侵袭性明显更强，但样本量太小，无法对数据进行具有统计学意义的比较。我们的研究结果表明，甲状腺滤泡癌（PTC）也可能含有PAX8-PPARγ融合基因，提示FVPTC的一个亚组具有FTA和FTC的一些分子特征。