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高分化甲状腺癌的诊断标准。

Diagnostic criteria in well-differentiated thyroid carcinomas.

作者信息

Fonseca Elsa, Soares Paula, Cardoso-Oliveira Manuel, Sobrinho-Simões Manuel

机构信息

Department of Pathology, Medical Faculty of the University of Porto, Porto, Portugal.

出版信息

Endocr Pathol. 2006 Summer;17(2):109-17. doi: 10.1385/ep:17:2:109.

DOI:10.1385/ep:17:2:109
PMID:17159243
Abstract

The criteria used for the differential diagnosis of well-differentiated thyroid tumors derived from follicular cells are reviewed taking into account the architectural characteristics together with the immunohistochemical and molecular features. The review is focused on follicular carcinoma, papillary carcinoma, follicular variant of papillary carcinoma, and oncocytic (Hürthle cell) tumors, as well as on the recently described borderline lesions: follicular and well-differentiated tumors of uncertain malignant potential, and well-differentiated carcinoma, not otherwise specified.

摘要

本文综合考虑结构特征、免疫组化及分子特征,对来源于滤泡细胞的高分化甲状腺肿瘤的鉴别诊断标准进行综述。综述聚焦于滤泡癌、乳头状癌、乳头状癌滤泡变异型、嗜酸细胞(许特莱细胞)肿瘤,以及最近描述的交界性病变:恶性潜能不确定的滤泡性和高分化肿瘤,以及未另行特指的高分化癌。

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Diagnostic criteria in well-differentiated thyroid carcinomas.高分化甲状腺癌的诊断标准。
Endocr Pathol. 2006 Summer;17(2):109-17. doi: 10.1385/ep:17:2:109.
2
Follicular thyroid carcinoma.滤泡状甲状腺癌。
Mod Pathol. 2011 Apr;24 Suppl 2:S10-8. doi: 10.1038/modpathol.2010.133.
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Semin Diagn Pathol. 2013 Aug;30(3):178-85. doi: 10.1053/j.semdp.2013.06.004.
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JAMA Oncol. 2016 Aug 1;2(8):1005-6. doi: 10.1001/jamaoncol.2016.0714.
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Impact of Reclassification on Thyroid Nodules with Architectural Atypia: From Non-Invasive Encapsulated Follicular Variant Papillary Thyroid Carcinomas to Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features.重新分类对具有结构异型性的甲状腺结节的影响:从非侵袭性包裹性滤泡型乳头状甲状腺癌到具有乳头状核特征的非侵袭性滤泡性甲状腺肿瘤。
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Comparing Clinicopathologic and Radiographic Findings Between TT-UMP, Classical, and Non-Encapsulated Follicular Variants of Papillary Thyroid Carcinomas.比较甲状腺乳头状癌的TT-UMP、经典型和非包膜滤泡型变体之间的临床病理及影像学表现
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Cytopathological review of patients that underwent thyroidectomies based on the diagnosis of papillary thyroid carcinoma by fine needle aspiration cytology but were later found to have benign tumors by histopathology.

本文引用的文献

1
PAX8-PPARgamma rearrangement is frequently detected in the follicular variant of papillary thyroid carcinoma.PAX8-PPARγ重排在甲状腺乳头状癌滤泡变体中经常被检测到。
J Clin Endocrinol Metab. 2006 Jan;91(1):213-20. doi: 10.1210/jc.2005-1336. Epub 2005 Oct 11.
2
Molecular pathology of well-differentiated thyroid carcinomas.高分化甲状腺癌的分子病理学
Virchows Arch. 2005 Nov;447(5):787-93. doi: 10.1007/s00428-005-0065-5. Epub 2005 Sep 28.
3
Usefulness of HBME-1, cytokeratin 19 and galectin-3 immunostaining in the diagnosis of thyroid malignancy.
对因细针穿刺细胞学检查诊断为甲状腺乳头状癌而行甲状腺切除术的患者进行细胞病理学检查,但后来通过组织病理学检查发现为良性肿瘤。
Surg Today. 2013 Jun;43(6):632-7. doi: 10.1007/s00595-012-0362-y. Epub 2012 Oct 18.
4
Mouse models of follicular and papillary thyroid cancer progression.滤泡性和乳头状甲状腺癌进展的小鼠模型。
Front Endocrinol (Lausanne). 2012 Jan 10;2:119. doi: 10.3389/fendo.2011.00119. eCollection 2011.
5
Thyroid tumours of uncertain malignant potential: frequency and diagnostic reproducibility.恶性潜能不确定的甲状腺肿瘤:发生率及诊断可重复性
Virchows Arch. 2009 Jul;455(1):21-33. doi: 10.1007/s00428-009-0798-7. Epub 2009 Jun 20.
6
Insulin-like growth factor mRNA binding protein 3 (IMP3) is differentially expressed in benign and malignant follicular patterned thyroid tumors.胰岛素样生长因子mRNA结合蛋白3(IMP3)在良性和恶性滤泡型甲状腺肿瘤中表达存在差异。
Endocr Pathol. 2009 Fall;20(3):149-57. doi: 10.1007/s12022-009-9079-x.
HBME-1、细胞角蛋白19和半乳糖凝集素-3免疫染色在甲状腺恶性肿瘤诊断中的应用价值。
Histopathology. 2005 Oct;47(4):391-401. doi: 10.1111/j.1365-2559.2005.02221.x.
4
BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer.BRAF突变预示着甲状腺乳头状癌的临床预后较差。
J Clin Endocrinol Metab. 2005 Dec;90(12):6373-9. doi: 10.1210/jc.2005-0987. Epub 2005 Sep 20.
5
A subset of the follicular variant of papillary thyroid carcinoma harbors the PAX8-PPARgamma translocation.甲状腺乳头状癌滤泡变体的一个亚群存在PAX8-PPARγ易位。
Int J Surg Pathol. 2005 Jul;13(3):235-8. doi: 10.1177/106689690501300301.
6
Independent clonal origins of distinct tumor foci in multifocal papillary thyroid carcinoma.多灶性乳头状甲状腺癌中不同肿瘤病灶的独立克隆起源
N Engl J Med. 2005 Jun 9;352(23):2406-12. doi: 10.1056/NEJMoa044190.
7
Type and prevalence of BRAF mutations are closely associated with papillary thyroid carcinoma histotype and patients' age but not with tumour aggressiveness.BRAF突变的类型和发生率与甲状腺乳头状癌的组织类型及患者年龄密切相关,但与肿瘤侵袭性无关。
Virchows Arch. 2005 Jun;446(6):589-95. doi: 10.1007/s00428-005-1236-0. Epub 2005 May 19.
8
Adenomas and follicular carcinomas of the thyroid display two major patterns of chromosomal changes.甲状腺腺瘤和滤泡癌呈现出两种主要的染色体变化模式。
J Pathol. 2005 Jul;206(3):305-11. doi: 10.1002/path.1772.
9
Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid.GRIM-19是一种参与线粒体代谢和细胞死亡的双功能基因,其体细胞和生殖系突变与富含线粒体的(许特耳细胞)甲状腺肿瘤有关。
Br J Cancer. 2005 May 23;92(10):1892-8. doi: 10.1038/sj.bjc.6602547.
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Hürthle (oncocytic) cell tumors of thyroid: etiopathogenesis, diagnosis and clinical significance.甲状腺许特尔(嗜酸性)细胞瘤:病因发病机制、诊断及临床意义
Int J Surg Pathol. 2005 Jan;13(1):29-35. doi: 10.1177/106689690501300104.