Huebner R E, Schein M F, Cauthen G M, Geiter L J, O'Brien R J
Division of Tuberculosis Elimination, Centers for Disease Control, Atlanta, GA.
Pediatr Infect Dis J. 1992 Jun;11(6):450-6. doi: 10.1097/00006454-199206000-00006.
One hundred twenty-three children with chronic cervical lymphadenopathy were skin-tested with purified protein derivative (PPD)-B (Mycobacterium intracellulare), PPD-Y (Mycobacterium kansasii), PPD-G (Mycobacterium scrofulaceum) (nontuberculous mycobacterial antigens (NTMags)) and PPD-T (Mycobacterium tuberculosis). Children with culture-confirmed mycobacterial disease had significantly larger reactions to NTMags and were 6 times more likely to have PPD-B responses of greater than or equal to 10 mm than those with negative microscopy/culture results. Children with acid-fast bacilli present in clinical specimens but with negative culture results were 3 times more likely to have greater than or equal to 10 mm induration to PPD-B than those with negative microscopy/culture results. In all groups except those with culture-confirmed M. tuberculosis, responses to PPD-T were significantly smaller than those to the NTMags. We conclude that NTMags, particularly PPD-B, may be useful in diagnosing childhood mycobacterial cervical adenopathy; however, their usefulness in distinguishing disease caused by M. tuberculosis from that resulting from other mycobacteria is unknown.
对123例慢性颈淋巴结病患儿进行了纯蛋白衍生物（PPD）-B（胞内分枝杆菌）、PPD-Y（堪萨斯分枝杆菌）、PPD-G（瘰疬分枝杆菌）（非结核分枝杆菌抗原（NTMags））和PPD-T（结核分枝杆菌）的皮肤试验。经培养确诊为分枝杆菌病的患儿对NTMags的反应明显更大，PPD-B反应≥10mm的可能性是显微镜检查/培养结果为阴性患儿的6倍。临床标本中存在抗酸杆菌但培养结果为阴性的患儿，PPD-B硬结≥10mm的可能性是显微镜检查/培养结果为阴性患儿的3倍。除培养确诊为结核分枝杆菌的组外，所有组对PPD-T的反应均明显小于对NTMags的反应。我们得出结论，NTMags，尤其是PPD-B，可能有助于诊断儿童分枝杆菌性颈淋巴结病；然而，它们在区分结核分枝杆菌引起的疾病与其他分枝杆菌引起的疾病方面的有用性尚不清楚。
