Vandiviere H M, Dillon M, Melvin I G
South Med J. 1987 Jan;80(1):5-9. doi: 10.1097/00007611-198701000-00002.
Purified protein derivatives (PPDs) prepared from M tuberculosis (PPD-S), M kansasii (PPD-Y), M scrofulaceum (PPD-G), M avium (PPD-A), M intracellulare (PPD-B), and M fortuitum (PPD-F) were used simultaneously as skin tests to elicit profiles of reactivity in patients with clinical pulmonary disease roentgenologically suggestive of mycobacteriosis. These profiles were useful in delineating the specific cause of mycobacterial disease weeks before bacteriologic confirmation by culture, and they provided a basis for early treatment. When bacteriologic confirmation was attained, the diagnosis suggested by skin testing was correct. Treatment regimens for non-M tuberculosis (atypical) mycobacterial disease varied: a two- to three-drug regimen in the treatment of M avium or M intracellulare disease was ineffective and inappropriate, whereas a five-drug regimen without surgical excision of residual disease produced good results. Combining surgical resection with the five-drug regimen before and after operation produced the best results, however, with all patients showing apparent cure.
由结核分枝杆菌（PPD-S）、堪萨斯分枝杆菌（PPD-Y）、瘰疬分枝杆菌（PPD-G）、鸟分枝杆菌（PPD-A）、胞内分枝杆菌（PPD-B）和偶然分枝杆菌（PPD-F）制备的纯化蛋白衍生物（PPD）同时用作皮肤试验，以引发临床肺部疾病患者的反应性特征，这些患者的影像学表现提示分枝杆菌病。这些特征有助于在通过培养进行细菌学确认前数周确定分枝杆菌病的具体病因，并为早期治疗提供依据。当获得细菌学确认时，皮肤试验提示的诊断是正确的。非结核（非典型）分枝杆菌病的治疗方案各不相同：治疗鸟分枝杆菌或胞内分枝杆菌病的两药或三药方案无效且不合适，而不手术切除残留病灶的五药方案效果良好。然而，手术切除与术前术后的五药方案相结合产生了最佳效果，所有患者均显示明显治愈。
