Suppr超能文献

对铁振动的直接探测阐明了血红素蛋白的一氧化氮激活过程。

Direct probe of iron vibrations elucidates NO activation of heme proteins.

作者信息

Zeng Weiqiao, Silvernail Nathan J, Wharton David C, Georgiev Georgi Y, Leu Bogdan M, Scheidt W Robert, Zhao Jiyong, Sturhahn Wolfgang, Alp E Ercan, Sage J Timothy

机构信息

Department of Physics and Center for Interdisciplinary Research on Complex Systems, Northeastern University, Boston, Massachusetts 02115, USA.

出版信息

J Am Chem Soc. 2005 Aug 17;127(32):11200-1. doi: 10.1021/ja051052x.

DOI:10.1021/ja051052x
PMID:16089422
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1502376/
Abstract

We use nuclear resonance vibrational spectroscopy (NRVS) to identify the Fe-NO stretching frequency in the NO adduct of myoglobin (MbNO) and in the related six-coordinate porphyrin Fe(TPP)(1-MeIm)(NO). Frequency shifts observed in MbNO Raman spectra upon isotopic substitution of Fe or the nitrosyl nitrogen confirm and extend the NRVS results. In contrast with previous assignments, the Fe-NO frequency of these six-coordinate complexes lies 70-100 cm-1 lower than in the analogous five-coordinate nitrosyl complexes, indicating a significant weakening of the Fe-NO bond in the presence of a trans imidazole ligand. This result supports proposed mechanisms for NO activation of heme proteins and underscores the value of NRVS as a direct probe of metal reactivity in complex biomolecules.

摘要

我们使用核共振振动光谱法（NRVS）来确定肌红蛋白（MbNO）的NO加合物以及相关的六配位卟啉Fe（TPP）（1-MeIm）（NO）中Fe-NO的伸缩频率。在对Fe或亚硝酰氮进行同位素取代时，MbNO拉曼光谱中观察到的频率变化证实并扩展了NRVS的结果。与先前的归属不同，这些六配位配合物的Fe-NO频率比类似的五配位亚硝酰配合物低70-100 cm-1，这表明在存在反式咪唑配体的情况下，Fe-NO键显著减弱。这一结果支持了所提出的血红素蛋白NO活化机制，并强调了NRVS作为复杂生物分子中金属反应性直接探针的价值。

相似文献

1
Direct probe of iron vibrations elucidates NO activation of heme proteins.
J Am Chem Soc. 2005 Aug 17;127(32):11200-1. doi: 10.1021/ja051052x.
2
Oriented single-crystal nuclear resonance vibrational spectroscopy of [Fe(TPP)(MI)(NO)]: quantitative assessment of the trans effect of NO.
Inorg Chem. 2010 Aug 2;49(15):7197-215. doi: 10.1021/ic1010677.
3
Direct determination of the complete set of iron normal modes in a porphyrin-imidazole model for carbonmonoxy-heme proteins: [Fe(TPP)(CO)(1-MeIm)].
J Am Chem Soc. 2003 Jun 11;125(23):6927-36. doi: 10.1021/ja028219w.
4
Characterization of ferrous FixL-nitric oxide adducts by resonance Raman spectroscopy.
Biochemistry. 1997 Apr 8;36(14):4178-87. doi: 10.1021/bi9628230.
5
Quantitative vibrational dynamics of iron in nitrosyl porphyrins.
J Am Chem Soc. 2004 Apr 7;126(13):4211-27. doi: 10.1021/ja038526h.
6
Binding of nitric oxide and carbon monoxide to soluble guanylate cyclase as observed with Resonance raman spectroscopy.
Biochemistry. 1996 Feb 6;35(5):1540-7. doi: 10.1021/bi952440m.
7
Naked five-coordinate Fe(III)(NO) porphyrin complexes: vibrational and reactivity features.
Inorg Chem. 2011 May 16;50(10):4445-52. doi: 10.1021/ic200073v. Epub 2011 Apr 8.
8
Electronic structure of six-coordinate iron(III)-porphyrin NO adducts: the elusive iron(III)-NO(radical) state and its influence on the properties of these complexes.
J Am Chem Soc. 2008 Nov 19;130(46):15288-303. doi: 10.1021/ja801860u. Epub 2008 Oct 23.
9
Nuclear resonance vibrational spectroscopy applied to [Fe(OEP)(NO)]: the vibrational assignments of five-coordinate ferrous heme-nitrosyls and implications for electronic structure.
Inorg Chem. 2010 May 3;49(9):4133-48. doi: 10.1021/ic902181e.
10
Nuclear resonance vibrational spectroscopy--NRVS.
J Inorg Biochem. 2005 Jan;99(1):60-71. doi: 10.1016/j.jinorgbio.2004.11.004.

引用本文的文献

1
Modeling nuclear resonance vibrational spectroscopic data of binuclear non-heme iron enzymes using density functional theory.
Can J Chem. 2014 Oct;92(10):975-978. doi: 10.1139/cjc-2014-0067. Epub 2014 Apr 15.
2
What Can Be Learned from Nuclear Resonance Vibrational Spectroscopy: Vibrational Dynamics and Hemes.
Chem Rev. 2017 Oct 11;117(19):12532-12563. doi: 10.1021/acs.chemrev.7b00295. Epub 2017 Sep 18.
3
3D Motions of Iron in Six-Coordinate {FeNO}(7) Hemes by Nuclear Resonance Vibration Spectroscopy.
Chemistry. 2016 Apr 25;22(18):6323-6332. doi: 10.1002/chem.201505155. Epub 2016 Mar 21.
4
Recent advances in biosynthetic modeling of nitric oxide reductases and insights gained from nuclear resonance vibrational and other spectroscopic studies.
Inorg Chem. 2015 Oct 5;54(19):9317-29. doi: 10.1021/acs.inorgchem.5b01105. Epub 2015 Aug 14.
5
Nuclear resonance vibrational spectroscopy (NRVS) of rubredoxin and MoFe protein crystals.
Hyperfine Interact. 2013 Dec;222(2 Suppl):77-90. doi: 10.1007/s10751-012-0643-2.
6
Comprehensive Fe-ligand vibration identification in {FeNO}6 hemes.
J Am Chem Soc. 2014 Dec 31;136(52):18100-10. doi: 10.1021/ja5105766. Epub 2014 Dec 18.
7
The diagnostic vibrational signature of pentacoordination in heme carbonyls.
J Am Chem Soc. 2014 Jul 16;136(28):9818-21. doi: 10.1021/ja503191z. Epub 2014 Jul 7.
8
Anisotropic iron motion in nitrosyl iron porphyrinates: natural and synthetic hemes.
Inorg Chem. 2014 Mar 3;53(5):2582-90. doi: 10.1021/ic4028964. Epub 2014 Feb 14.
9
Ambidentate H-bonding of NO and O2 in heme proteins.
J Inorg Biochem. 2012 Oct;115:204-10. doi: 10.1016/j.jinorgbio.2012.05.013. Epub 2012 Jun 1.
10
Nuclear inelastic scattering and Mössbauer spectroscopy as local probes for ligand binding modes and electronic properties in proteins: vibrational behavior of a ferriheme center inside a β-barrel protein.
J Am Chem Soc. 2012 Mar 7;134(9):4216-28. doi: 10.1021/ja210067t. Epub 2012 Feb 27.

本文引用的文献

1
Femtomolar sensitivity of a NO sensor from Clostridium botulinum.
Science. 2004 Nov 26;306(5701):1550-3. doi: 10.1126/science.1103596. Epub 2004 Oct 7.
2
Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases.
Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12854-9. doi: 10.1073/pnas.0405188101. Epub 2004 Aug 23.
3
Quantitative vibrational dynamics of iron in nitrosyl porphyrins.
J Am Chem Soc. 2004 Apr 7;126(13):4211-27. doi: 10.1021/ja038526h.
4
Crystal structures of ferrous horse heart myoglobin complexed with nitric oxide and nitrosoethane.
Proteins. 2003 Nov 1;53(2):182-92. doi: 10.1002/prot.10495.
5
Five- to six-coordination in (nitrosyl)iron(II) porphyrinates: effects of binding the sixth ligand.
Inorg Chem. 2003 Sep 8;42(18):5722-34. doi: 10.1021/ic034473t.
6
Direct determination of the complete set of iron normal modes in a porphyrin-imidazole model for carbonmonoxy-heme proteins: [Fe(TPP)(CO)(1-MeIm)].
J Am Chem Soc. 2003 Jun 11;125(23):6927-36. doi: 10.1021/ja028219w.
7
FeNO structure in distal pocket mutants of myoglobin based on resonance Raman spectroscopy.
Biochemistry. 2003 May 6;42(17):4896-903. doi: 10.1021/bi026395b.
8
Observation of Fe-H/D modes by nuclear resonant vibrational spectroscopy.
J Am Chem Soc. 2003 Apr 9;125(14):4016-7. doi: 10.1021/ja028767+.
9
Iron normal mode dynamics in (nitrosyl)iron(II)tetraphenylporphyrin from X-ray nuclear resonance data.
Biophys J. 2002 Jun;82(6):2951-63. doi: 10.1016/S0006-3495(02)75636-1.
10
Six- to five-coordinate heme-nitrosyl conversion in cytochrome c' and its relevance to guanylate cyclase.
Biochemistry. 2002 Feb 19;41(7):2353-60. doi: 10.1021/bi011419k.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验