人类疱疹病毒8型：生物学特性及其在卡波西肉瘤和其他艾滋病相关恶性肿瘤发病机制中的作用
Human herpesvirus 8: biology and role in the pathogenesis of Kaposi's sarcoma and other AIDS-related malignancies.
作者信息
Viejo-Borbolla Abel, Ottinger Matthias, Schulz Thomas F
机构信息
Department of Virology, Hannover Medical School, Carl-Neuberg-Strasse1, D-30625 Hannover, Germany.
出版信息
Curr HIV/AIDS Rep. 2004 Apr;1(1):5-11. doi: 10.1007/s11904-004-0001-3.
Human herpesvirus type 8, or Kaposi's sarcoma-associated herpesvirus (KSHV), is the only known human g(2) herpesvirus (rhadinovirus) and the most recently discovered tumor virus. KSHV is associated with Kaposi's sarcoma and two other lymphoproliferative disorders in the AIDS setting: primary effusion lymphoma and the plasma cell variant of multicentric Castleman's disease. This review offers an update on the epidemiology and the role of KSHV genes in the development of disease.
人疱疹病毒8型，即卡波西肉瘤相关疱疹病毒（KSHV），是已知的唯一一种人类γ疱疹病毒（嗜淋巴细胞病毒），也是最近发现的肿瘤病毒。KSHV与卡波西肉瘤以及艾滋病背景下的另外两种淋巴增生性疾病有关：原发性渗出性淋巴瘤和多中心Castleman病的浆细胞变异型。本文综述了KSHV的流行病学以及KSHV基因在疾病发展中的作用的最新情况。
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