泛素系统和肿瘤病毒在艾滋病相关癌症中的作用。
Role of the ubiquitin system and tumor viruses in AIDS-related cancer.
作者信息
Shackelford Julia, Pagano Joseph S
机构信息
Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.
出版信息
BMC Biochem. 2007 Nov 22;8 Suppl 1(Suppl 1):S8. doi: 10.1186/1471-2091-8-S1-S8.
Abstract
Tumor viruses are linked to approximately 20% of human malignancies worldwide. This review focuses on examples of human oncogenic viruses that manipulate the ubiquitin system in a subset of viral malignancies; those associated with AIDS. The viruses include Kaposi's sarcoma herpesvirus, Epstein-Barr virus and human papilloma virus, which are causally linked to Kaposi's sarcoma, certain B-cell lymphomas and cervical cancer, respectively. We discuss the molecular mechanisms by which these viruses subvert the ubiquitin system and potential viral targets for anti-cancer therapy from the perspective of this system. Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com).
摘要
肿瘤病毒与全球约20%的人类恶性肿瘤有关。本综述重点关注在一部分病毒性恶性肿瘤（即与艾滋病相关的恶性肿瘤）中操纵泛素系统的人类致癌病毒实例。这些病毒包括卡波西肉瘤疱疹病毒、爱泼斯坦-巴尔病毒和人乳头瘤病毒，它们分别与卡波西肉瘤、某些B细胞淋巴瘤和宫颈癌存在因果关系。我们从该系统的角度讨论这些病毒颠覆泛素系统的分子机制以及抗癌治疗的潜在病毒靶点。出版历史：转载自Current BioData的靶向蛋白质数据库（TPdb；http://www.targetedproteinsdb.com）。
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