Ishikawa T, Takayama S, Kitagawa T, Kawachi T, Sugimura T
J Cancer Res Clin Oncol. 1979;95(3):221-4. doi: 10.1007/BF00410642.
Two new gamma-carboline derivatives, 3-amino-1,4-dimethyl-5H pyrido[4,3-b]indole (Trp-P-1) and 3-amino-1-methyl-5H pyrido[4,3-b]indole (Trp-P-2), isolated from the pyrolysis products of tryptophan, were found to be potent mutagens. When weanling rats were injected with Trp-P-1 and then given diet containing phenobarbital, they developed enzyme-altered islands in the liver. Since these islands are considered to be formed by immediate progeny of "initiated cells" and cell precursors in hepatocarcinogenesis, Trp-P-1 may well be carcinogenic in rat liver.
从色氨酸的热解产物中分离出的两种新的γ-咔啉衍生物，即3-氨基-1,4-二甲基-5H吡啶并[4,3-b]吲哚（Trp-P-1）和3-氨基-1-甲基-5H吡啶并[4,3-b]吲哚（Trp-P-2），被发现是强力诱变剂。给断奶大鼠注射Trp-P-1，然后给予含苯巴比妥的饮食，它们的肝脏中出现了酶改变岛。由于这些岛被认为是由肝癌发生过程中“启动细胞”的直接后代和细胞前体形成的，Trp-P-1很可能在大鼠肝脏中具有致癌性。
