Fujii K, Nomoto K, Nakamura K
Department of Pathology, University of Tsukuba, Ibaraki, Japan.
Carcinogenesis. 1987 Nov;8(11):1721-3. doi: 10.1093/carcin/8.11.1721.
3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) or 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2), which is a potent mutagen from pyrolysates of tryptophan, was given subcutaneously to neonatal ICR mice, and all animals were observed for 1 year. Tumors of the livers and lymphoreticular tissue were induced. In the mice given Trp-P-1, the incidences of these tumors were as follows: liver tumors in 45% of the males; malignant lymphoma in 13% of the males and in 24% of the females. In the mice given Trp-P-2, the incidences of liver tumors in the males were dose-dependent (12.5 mg/kg, 12%; 25 mg/kg, 18%), while those of malignant lymphoma varied within a range from 5 to 19%. Statistical analysis revealed that the incidences of the liver tumor in the mice given Trp-P-1 or Trp-P-2 and those of lymphoma in the mice given Trp-P-1 were significantly higher than those of the controls. In the control mice, the incidences of tumors were as follows: malignant lymphoma in 5% of the females; lung tumor in 14% of both sexes.
将色氨酸热解产物中的一种强效诱变剂3-氨基-1,4-二甲基-5H-吡啶并[4,3-b]吲哚（Trp-P-1）或3-氨基-1-甲基-5H-吡啶并[4,3-b]吲哚（Trp-P-2）皮下注射给新生ICR小鼠，并对所有动物进行1年的观察。诱发了肝脏和淋巴网状组织的肿瘤。在给予Trp-P-1的小鼠中，这些肿瘤的发生率如下：雄性小鼠肝脏肿瘤发生率为45%；雄性小鼠恶性淋巴瘤发生率为13%，雌性小鼠为24%。在给予Trp-P-2的小鼠中，雄性小鼠肝脏肿瘤的发生率呈剂量依赖性（12.5 mg/kg，12%；25 mg/kg，18%），而恶性淋巴瘤的发生率在5%至19%之间变化。统计分析表明，给予Trp-P-1或Trp-P-2的小鼠肝脏肿瘤发生率以及给予Trp-P-1的小鼠淋巴瘤发生率显著高于对照组。在对照小鼠中，肿瘤发生率如下：雌性小鼠恶性淋巴瘤发生率为5%；两性小鼠肺肿瘤发生率均为14%。
