Georgopoulos A P, Ashe J, Smyrnis N, Taira M
Brain Sciences Center, Department of Veterans Affairs Medical Center, Minneapolis, MN 55455.
Science. 1992 Jun 19;256(5064):1692-5. doi: 10.1126/science.256.5064.1692.
The relation of cellular activity in the motor cortex to the direction of two-dimensional isometric force was investigated under dynamic conditions in monkeys. A task was designed so that three force variables were dissociated: the force exerted by the subject, the net force, and the change in force. Recordings of neuronal activity in the motor cortex revealed that the activity of single cells was directionally tuned and that this tuning was invariant across different directions of a bias force. Cell activity was not related to the direction of force exerted by the subject, which changed drastically as the bias force changed. In contrast, the direction of net force, the direction of force change, and the visually instructed direction all remained quite invariant and congruent and could be the directional variables, alone or in combination, to which cell activity might relate.
在动态条件下对猴子的运动皮层细胞活动与二维等长力方向之间的关系进行了研究。设计了一项任务，以便分离出三个力变量：受试者施加的力、合力和力的变化。运动皮层神经元活动的记录显示，单个细胞的活动具有方向调谐性，并且这种调谐在偏置力的不同方向上是不变的。细胞活动与受试者施加的力的方向无关，该方向会随着偏置力的变化而急剧改变。相比之下，合力方向、力变化方向和视觉指示方向都保持相当不变且一致，并且可能是细胞活动可能与之相关的单独或组合的方向变量。
