Anderson Mark L
Research and Development, Triarco Industries, Wayne, NJ 07470, USA.
J Herb Pharmacother. 2005;5(1):17-26.
Inhibition of 5alpha-reductase has been reported to decrease the symptoms of benign prostate hyperplasia (BPH) and possibly inhibit or help treat prostate cancer. Saw Palmetto berry lipid extract (SPLE) is reported to inhibit 5alpha-reductase and decrease the clinical symptoms of BPH. Epidemiologic studies report that carotenoids such as lycopene may inhibit prostate cancer. In this investigation the effect of the carotenoid astaxanthin, and SPLE were examined for their effect on 5alpha-reductase inhibition as well as the growth of prostatic carcinoma cells in vitro. These studies support patent #6,277,417 B1. The results show astaxanthin demonstrated 98% inhibition of 5alpha-reductase at 300 microg/mL in vitro. Alphastat, the combination of astaxanthin and SPLE, showed a 20% greater inhibition of 5alpha-reductase than SPLE alone n vitro. A nine day treatment of prostatic carcinoma cells with astaxanthin in vitro produced a 24% decrease in growth at 0.1 mcg/mL and a 38% decrease at 0.01 mcg/mL. SPLE showed a 34% decrease at 0.1 mcg/mL.
Low levels of carotenoid astaxanthin inhibit 5alpha-reductase and decrease the growth of human prostatic cancer cells in vitro. Astaxanthin added to SPLE shows greater inhibition of 5alpha-reductase than SPLE alone in vitro.
据报道，抑制5α-还原酶可减轻良性前列腺增生（BPH）的症状，并可能抑制或有助于治疗前列腺癌。锯叶棕果脂质提取物（SPLE）据报道可抑制5α-还原酶并减轻BPH的临床症状。流行病学研究报告称，类胡萝卜素如番茄红素可能抑制前列腺癌。在本研究中，检测了类胡萝卜素虾青素和SPLE对5α-还原酶抑制作用以及体外前列腺癌细胞生长的影响。这些研究支持专利#6,277,417 B1。结果显示，虾青素在体外300微克/毫升浓度下对5α-还原酶的抑制率达98%。Alphastat，即虾青素与SPLE的组合，在体外对5α-还原酶的抑制作用比单独使用SPLE高20%。在体外对前列腺癌细胞进行九天的虾青素处理，在0.1微克/毫升浓度下细胞生长减少24%，在0.01微克/毫升浓度下减少38%。SPLE在0.1微克/毫升浓度下细胞生长减少34%。
低水平的类胡萝卜素虾青素在体外可抑制5α-还原酶并减少人前列腺癌细胞的生长。在SPLE中添加虾青素在体外对5α-还原酶的抑制作用比单独使用SPLE更强。
