Vlieg-Boerstra B J, van der Heide S, Oude Elberink J N G, Kluin-Nelemans J C, Dubois A E J
Beatrix Children's Hospital, University Medical Centre Groningen, Netherlands.
Neth J Med. 2005 Jul-Aug;63(7):244-9.
It has been suggested that normal concentrations of biogenic amines and 'histamine-releasing foods' may exacerbate symptoms in mastocytosis. The purpose of this study was to look for scientific evidence in the literature on diets restricted in biogenic amines and histamine-releasing foods in the treatment of mastocytosis.
Medline (1966 to 2004), Cinahl (1982 to 2004) and the Cochraine Library were searched for double-blind placebo-controlled food challenge (DBPCFC) studies with biogenic amines and/or histamine-releasing foods in mastocytosis.
No studies employing DBPCFC with dietary biogenic amines or histamine-releasing foods in mastocytosis were found. Only a few in vitro studies in other diseases, animal studies and studies in humans in which histamine-releasing agents were incubated directly with duodenal tissues were found. One case was reported of severe adverse reactions to alcohol in mastocytosis, objectified by an open challenge.
Despite the widespread belief that biogenic amines and histamine-releasing foods may cause allergy-like, non-IgE-mediated symptoms in certain patients, the role of diets restricted in biogenic amines and histamine-releasing foods in the treatment of mastosytosis remains hypothetical but worthy of further investigation. There is some evidence for adverse reactions to alcohol in mastocytosis.
有人提出，生物胺和“组胺释放性食物”的正常浓度可能会加重肥大细胞增多症的症状。本研究的目的是在文献中寻找关于限制生物胺和组胺释放性食物的饮食疗法治疗肥大细胞增多症的科学证据。
检索了Medline（1966年至2004年）、Cinahl（1982年至2004年）和Cochrane图书馆，查找有关肥大细胞增多症中生物胺和/或组胺释放性食物的双盲安慰剂对照食物激发试验（DBPCFC）研究。
未找到在肥大细胞增多症中使用生物胺或组胺释放性食物进行DBPCFC的研究。仅发现了一些关于其他疾病的体外研究、动物研究以及组胺释放剂与十二指肠组织直接孵育的人体研究。有一例报告称，肥大细胞增多症患者对酒精产生严重不良反应，并通过开放性激发试验得到证实。
尽管人们普遍认为生物胺和组胺释放性食物可能会在某些患者中引起类似过敏的非IgE介导症状，但限制生物胺和组胺释放性食物的饮食疗法在治疗肥大细胞增多症中的作用仍属假设，但值得进一步研究。有一些证据表明肥大细胞增多症患者对酒精有不良反应。
