Schutte R, Huisman H W, Schutte A E, Malan N T
School of Physiology, Nutrition and Consumer Sciences, North-West University, Potchefstroom, South Africa.
J Hum Hypertens. 2005 Dec;19(12):933-9. doi: 10.1038/sj.jhh.1001922.
The comparison of the associations between chronically elevated leptin levels and cardiovascular function in obese Africans and Caucasians has not yet been determined. Therefore, the aim of this study was to compare leptin's associations with cardiovascular function in obese African and obese Caucasian women to determine whether leptin's associations differ between these two groups. This study consisted of two case-case control studies. The first study included a sample of 102 apparently healthy African women and the second, 115 apparently healthy Caucasian women. All lean and obese subjects were selected from each study. The Finometer apparatus was used to obtain a more elaborate cardiovascular profile. Serum leptin levels, insulin levels and the lipid profile were determined. Stroke volume (SV) and cardiac output (CO) were significantly (P< or =0.01) elevated in both obese African and Caucasian groups compared to their lean controls. Total peripheral resistance (TPR) was significantly decreased and arterial compliance (C(W)) significantly increased in both obese African and Caucasian groups. In the obese Caucasian group, diastolic blood pressure (DBP) was significantly (P< or =0.01) lower, SV and C(W) significantly higher (P< or =0.01) and TPR significantly lower compared to the age, body mass index (BMI), and leptin-matched obese African group. After adjusting for age and BMI, leptin correlated negatively with DBP (P< or =0.05; r=-0.33) and TPR (P< or =0.05; r=-0.36) in the obese Caucasian group, but not in the obese African group. Even though leptin levels were similar in obese African and Caucasian women, leptin is favourably associated with vascular function in obese Caucasians, but not in obese Africans.
肥胖非洲人和高加索人慢性升高的瘦素水平与心血管功能之间的关联尚未确定。因此，本研究的目的是比较肥胖非洲女性和肥胖高加索女性中瘦素与心血管功能的关联，以确定这两组之间瘦素的关联是否存在差异。本研究包括两项病例对照研究。第一项研究纳入了102名表面健康的非洲女性样本，第二项研究纳入了115名表面健康的高加索女性样本。每项研究均选取了所有瘦人和肥胖受试者。使用Finometer仪器获取更详细的心血管状况。测定血清瘦素水平、胰岛素水平和血脂谱。与各自的瘦素对照组相比，肥胖非洲人和高加索人组的每搏输出量（SV）和心输出量（CO）均显著升高（P≤0.01）。肥胖非洲人和高加索人组的总外周阻力（TPR）均显著降低，动脉顺应性（C(W)）均显著升高。与年龄、体重指数（BMI）和瘦素匹配的肥胖非洲人组相比，肥胖高加索人组的舒张压（DBP）显著更低（P≤0.01），SV和C(W)显著更高（P≤0.01），TPR显著更低。在调整年龄和BMI后，瘦素与肥胖高加索人组的DBP（P≤0.05；r=-0.33）和TPR（P≤0.05；r=-0.36）呈负相关，但在肥胖非洲人组中无此相关性。尽管肥胖非洲女性和高加索女性的瘦素水平相似，但瘦素与肥胖高加索人的血管功能呈正相关，而与肥胖非洲人无关。
