Laforest Laurent, Bousquet Jean, Neukirch Françoise, Aubier Michel, Pietri Guilhem, Devouassoux Gilles, Pacheco Yves, Van Ganse Eric
Pharmacoepidemiology Unit, EA 3091, University Hospital, Lyon, France.
Ann Allergy Asthma Immunol. 2005 Jul;95(1):26-32. doi: 10.1016/S1081-1206(10)61184-2.
Quality of life (QOL) is an important outcome in asthma and seasonal allergic rhinitis (SAR), and its determinants are imperfectly understood. More specifically, the influence of sociodemographic factors on QOL in patients with SAR has been so far little investigated.
To examine the changes of QOL during the pollen season in patients with isolated SAR or SAR associated with asthma.
A prospective cohort study was conducted in southern France. Outpatients aged 18 to 60 years and regularly treated by respiratory physicians for SAR (with or without associated asthma) were identified. Patients were recruited before the grass or ragweed pollination period. At peak pollination, patients completed the French versions of the Mini Rhino-conjunctivitis Quality of Life Questionnaire (mini-RQLQ) and the 12-item Short-Form Health Survey (SF-12) physical component summary (PCS) and mental component summary (MCS).
A total of 135 patients was included, 83 with isolated SAR and 52 with associated asthma (mean age, 35.4 years; SD, 10.6 years; 56% female). At pollen peak, QOL scores were lower in women for all instruments, with significant effects on SF-12 MCS and PCS scores in multivariate analyses. Likewise, a university-level education was an independent predictor of higher SF-12 PCS and MCS scores. Patients who lived in rural areas had significantly poorer QOL at pollen peak, as measured by the mini-RQLQ (P = .002) and SF-12 PCS (P = .008). No influence of age, presence of an animal at home, or smoking status could be identified on any QOL scores.
Being a woman, living in the countryside, and having a lower education level were all independent predictors of poorer QOL of SAR patients. These factors must be taken into account when interpreting QOL of patients with SAR. Further studies are needed to confirm these results.
生活质量（QOL）是哮喘和季节性变应性鼻炎（SAR）的一项重要预后指标，但其决定因素尚未完全明确。更具体地说，社会人口学因素对SAR患者生活质量的影响迄今鲜有研究。
研究单纯性SAR或合并哮喘的SAR患者在花粉季节生活质量的变化。
在法国南部进行了一项前瞻性队列研究。纳入年龄在18至60岁之间、因SAR（伴或不伴哮喘）接受呼吸内科医生定期治疗的门诊患者。在禾本科植物或豚草授粉期之前招募患者。在授粉高峰期，患者完成法语版的迷你鼻结膜炎生活质量问卷（mini-RQLQ）以及12项简明健康调查（SF-12）的身体成分总结（PCS）和精神成分总结（MCS）。
共纳入135例患者，其中83例为单纯性SAR，52例合并哮喘（平均年龄35.4岁；标准差10.6岁；56%为女性）。在花粉高峰期，所有量表的生活质量评分女性均较低，多因素分析显示对SF-12的MCS和PCS评分有显著影响。同样，大学学历是SF-12的PCS和MCS评分较高的独立预测因素。根据mini-RQLQ（P = 0.002）和SF-12的PCS（P = 0.008）测量，居住在农村地区的患者在花粉高峰期的生活质量明显较差。未发现年龄、家中是否饲养动物或吸烟状况对任何生活质量评分有影响。
女性、居住在农村以及教育水平较低均是SAR患者生活质量较差的独立预测因素。在解释SAR患者的生活质量时必须考虑这些因素。需要进一步研究来证实这些结果。
