Linneberg A, Dam Petersen K, Hahn-Pedersen J, Hammerby E, Serup-Hansen N, Boxall N
Research Centre for Prevention and Health, The Capital Region of Denmark, Copenhagen, Denmark ; Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark ; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Department of Business and Management, Faculty of Social Sciences, Aalborg University, Aalborg, Denmark.
Clin Mol Allergy. 2016 Sep 28;14:12. doi: 10.1186/s12948-016-0049-9. eCollection 2016.
This meta-analysis compared the health-related quality of life (HRQL) of patients with allergic rhinitis (AR) and/or allergic asthma (AA) caused by perennial house dust mite (HDM) versus AR and/or AA caused by seasonal pollen allergy. Following a systematic search, the identified studies used the disease-specific rhinitis quality of life questionnaire or generic instruments (SF-36 and SF-12). Summary estimates obtained by meta-analysis showed that HRQL in patients with perennial HDM allergy was significantly worse than that of patients with seasonal pollen allergy, when measured by both disease-specific and generic HRQL instruments, and was reflected by an impact on both physical and mental health. A systematic review of cost data on AR and AA in selected European countries demonstrated that the majority of the economic burden was indirectly caused by high levels of absenteeism and presenteeism; there was little or no evidence of increasing or decreasing cost trends. Increased awareness of the detrimental effects of AR and/or AA on patients' HRQL and its considerable cost burden might encourage early diagnosis and treatment, in order to minimize the disease burden and ensure beneficial and cost-effective outcomes.
这项荟萃分析比较了由常年屋尘螨（HDM）引起的过敏性鼻炎（AR）和/或过敏性哮喘（AA）患者与由季节性花粉过敏引起的AR和/或AA患者的健康相关生活质量（HRQL）。经过系统检索，纳入研究使用了疾病特异性鼻炎生活质量问卷或通用工具（SF - 36和SF - 12）。荟萃分析得出的汇总估计表明，无论是通过疾病特异性还是通用HRQL工具测量，常年HDM过敏患者的HRQL均显著低于季节性花粉过敏患者，且这体现在对身心健康的影响上。对选定欧洲国家AR和AA成本数据的系统评价表明，大部分经济负担是由高水平的旷工和出勤主义间接造成的；几乎没有证据表明成本有增加或减少的趋势。提高对AR和/或AA对患者HRQL的有害影响及其相当大的成本负担的认识，可能会鼓励早期诊断和治疗，以尽量减少疾病负担并确保有益且具有成本效益的结果。
