Chen Jennifer C, Brown Brian, Schmid Katrina L
Centre for Health Research-Optometry, Queensland University of Technology, Victoria Park Road, Kelvin Grove, Brisbane, Qld 4059, Australia.
Vision Res. 2006 Apr;46(8-9):1221-9. doi: 10.1016/j.visres.2005.06.030. Epub 2005 Aug 10.
It has been suggested that changes in the multifocal electroretinogram (mfERG) responses in myopes are primarily due to the increased axial length that accompanies myopia development. We investigated the characteristics of mfERG responses between emmetropes and myopes and determined the contribution of axial length to the mfERG data in 30 subjects (10 emmetropes and 20 myopes) using VERIS I. The amplitude and implicit time of the first positive peak (P1) of the first-order kernel were analyzed. We found that P1 implicit time in myopes was significantly longer by 1.3-3.1 ms than that of the emmetropes and this was not explained by the myopes having greater axial lengths than the emmetropes. Axial length contributed to 15% of the implicit time total variance while refractive error accounted for 27%. Delayed mfERG responses observed in myopes were not attributable to the anatomical change that accompanies myopia and may suggest underlying differences in retinal function that result from being myopic.
有人提出，近视患者多焦视网膜电图（mfERG）反应的变化主要是由于近视发展过程中眼轴长度增加所致。我们使用VERIS I研究了正视眼和近视眼之间mfERG反应的特征，并确定了30名受试者（10名正视眼和20名近视眼）的眼轴长度对mfERG数据的影响。分析了一阶核的第一个正峰（P1）的振幅和隐含时间。我们发现，近视眼的P1隐含时间比正视眼显著长1.3 - 3.1毫秒，而近视眼眼轴长度比正视眼长并不能解释这一现象。眼轴长度对隐含时间总方差的贡献为15%，而屈光不正占27%。在近视眼中观察到的mfERG反应延迟并非归因于近视伴随的解剖学变化，这可能表明近视导致视网膜功能存在潜在差异。
