Luu Chi D, Lau Adeline M I, Lee Shu-Yen
Singapore Eye Research Institute, Singapore; Singapore National Eye Centre, Singapore.
Arch Ophthalmol. 2006 Mar;124(3):328-34. doi: 10.1001/archopht.124.3.328.
To determine the correlation between multifocal electroretinogram (mfERG) parameters and the severity of myopia in adults and children.
Observational study.
Multifocal electroretinograms were recorded using the VERIS system from randomly selected eyes of 104 children and 31 adults with various degrees of myopia. Dawson, Trick, and Litzkow fiber electrodes were used and the pupil was dilated with 1% tropicamide. Subjective refraction was performed under cycloplegia and axial length measurement was determined by A-scan ultrasonography. The N1 (first negative trough), P1 (first positive peak), and N2 (second negative trough) components of the first-order kernel response of the mfERG were measured and correlated with the refractive data.
First-order kernel mfERG responses.
The N1, P1, and N2 amplitudes were significantly correlated with the severity of myopia in adult subjects (N1, r = 0.591, P = .001; P1, r = 0.682, P<.001; N2, r = 0.732, P<.001). The response amplitudes of N1, P1, and N2 decreased as the dioptric power of myopia increased. However, there were no significant correlations found between N1 (r = 0.073, P = .30), P1 (r = 0.071, P = .31), and N2 (r = 0.052, P = .46) amplitudes and the severity of myopia in children. The severity of myopia was also significantly correlated with N1 (r = -0.750, P<.001), P1 (r = -0.769, P<.001), and N2 (r = -0.664, P<.001) implicit times in adults with myopia, however, only the P1 (r = -0.166, P = .02) implicit time was significantly correlated with children with myopia.
There is a significant correlation between the refractive error and mfERG amplitude in adults with myopia; however, such a relationship is absent in children with myopia. These findings suggest that the severity of myopia has little influence on the ERG amplitude, at least in children.
确定多焦视网膜电图（mfERG）参数与成人及儿童近视严重程度之间的相关性。
观察性研究。
使用VERIS系统对104名儿童和31名患有不同程度近视的成人的随机选取的眼睛进行多焦视网膜电图记录。采用Dawson、Trick和Litzkow纤维电极，并用1%托吡卡胺散瞳。在睫状肌麻痹下进行主观验光，并通过A超超声检查确定眼轴长度。测量mfERG一阶核反应的N1（第一个负波谷）、P1（第一个正波峰）和N2（第二个负波谷）成分，并将其与屈光数据进行相关性分析。
一阶核mfERG反应。
在成年受试者中，N1、P1和N2波幅与近视严重程度显著相关（N1，r = 0.591，P = 0.001；P1，r = 0.682，P < 0.001；N2，r = 0.732，P < 0.001）。随着近视屈光度增加，N1、P1和N2的反应波幅降低。然而，在儿童中，未发现N1（r = 0.073，P = 0.30）、P1（r = 0.071，P = 0.31）和N2（r = 0.052，P = 0.46）波幅与近视严重程度之间存在显著相关性。在近视成人中，近视严重程度也与N1（r = -0.750，P < 0.001）、P1（r = -0.769，P < 0.001）和N2（r = -0.664，P < 0.001）的潜伏时间显著相关，然而，在近视儿童中，只有P1（r = -0.166，P = 0.02）的潜伏时间与近视显著相关。
近视成人的屈光不正与mfERG波幅之间存在显著相关性；然而，近视儿童中不存在这种关系。这些发现表明，近视严重程度对视网膜电图波幅影响较小，至少在儿童中如此。
