Küchle M, Nguyen N X, Horn F, Naumann G O
Department of Ophthalmology, University of Erlangen-Nürnberg, Germany.
Acta Ophthalmol (Copenh). 1992 Apr;70(2):201-8. doi: 10.1111/j.1755-3768.1992.tb04124.x.
We used the laser flare-cell meter to measure aqueous flare and aqueous 'cells' in 38 eyes of 38 patients with pseudoexfoliation, in 36 normal control eyes of 36 subjects, and in 19 eyes of 19 patients with chronic open-angle glaucoma unrelated to pseudoexfoliation. In pseudoexfoliation eyes, both aqueous flare (0.61 +/- 0.55 mg/ml human albumin equivalent) and aqueous 'cells' (mean 10.70, range 0-50.6 cells/0.075 mm3) were significantly higher than in the normal control group (flare 0.15 +/- 0.06 mg/ml, 'cells' 0.43, range 0-2, P less than 0.0001) and in the glaucoma group without pseudoexfoliation (flare 0.19 +/- 0.08 mg/ml, 'cells' 0.80, range 0-2.4, P less than 0.0001 and P less than 0.005). No significant difference could be found between the flare and cell counts of normal eyes and glaucoma eyes without pseudoexfoliation (P greater than 0.09, P greater than 0.05) and between PSX eyes with (18 eyes) and without (20 eyes) open-angle glaucoma (P greater than 0.99, P greater than 0.4). Our findings indicate that the blood-aqueous barrier is impaired in eyes with pseudoexfoliation, and that the laser flare-cell meter may be a useful tool to quantify these changes. These alterations of the blood-aqueous barrier need to be considered in medical therapy and intraocular surgery.
我们使用激光散射细胞仪对38例假性剥脱综合征患者的38只眼、36名受试者的36只正常对照眼以及19例与假性剥脱综合征无关的慢性开角型青光眼患者的19只眼进行房水闪光和房水“细胞”测量。在假性剥脱综合征眼中，房水闪光（0.61±0.55mg/ml人白蛋白当量）和房水“细胞”（平均10.70，范围0 - 50.6个细胞/0.075mm³）均显著高于正常对照组（闪光0.15±0.06mg/ml，“细胞”0.43，范围0 - 2，P<0.0001）以及无假性剥脱综合征的青光眼组（闪光0.19±0.08mg/ml，“细胞”0.80，范围0 - 2.4，P<0.0001和P<0.005）。正常眼与无假性剥脱综合征的青光眼眼之间的闪光和细胞计数无显著差异（P>0.09，P>0.05），假性剥脱综合征伴开角型青光眼的眼（18只眼）与不伴开角型青光眼的眼（20只眼）之间也无显著差异（P>0.99，P>0.4）。我们的研究结果表明，假性剥脱综合征患者的眼内血 - 房水屏障受损，激光散射细胞仪可能是量化这些变化的有用工具。在药物治疗和眼内手术中需要考虑血 - 房水屏障的这些改变。
