Kubota T, Motomatsu K, Sakamoto M, Honda T, Ishibashi T
Department of Ophthalmology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Graefes Arch Clin Exp Ophthalmol. 1996 May;234(5):285-7. doi: 10.1007/BF00220701.
The aim of the present study was to investigate the aqueous flare in eyes with senile disciform macular degeneration (SDMD), divided into different clinical stages, and the correlation between the aqueous flare and the area of the neovascular membrane.
Eighty-six eyes of 44 patients with SDMD were examined using a laser flare meter. The area of the neovascular membrane was measured by means of a digitizer in images obtained using indocyanine green videoangiography.
The mean value of the aqueous flare was 5.91 +/- 2.51 (photon count/ms) in 7 predisposing stage eyes, 5.68 +/- 1.64 in 15 initial stage eyes, 9.09 +/- 7.65 in 24 advanced form eyes, 5.40 +/- 1.42 in 11 disciform scar eyes, and 5.36 +/- 1.72 in 29 fellow eyes. The aqueous flare value was significantly (P < 0.01) higher in eyes with the advanced form of SDMD than in the fellow eyes. There were no significant differences in aqueous flare values between eyes with predisposing stage, initial stage, and disciform scar and fellow eyes. The aqueous flare value increased significantly with increasing area of neovascular membrane (R = 0.68, P < 0.01).
The present results suggest that the aqueous flare increases with increasing neovascular membrane area in eyes with SDMD, and decreases with scarization of the neovascular membrane.
本研究的目的是调查不同临床分期的老年性盘状黄斑变性（SDMD）患者眼内的房水闪光，以及房水闪光与新生血管膜面积之间的相关性。
使用激光房水闪光仪对44例SDMD患者的86只眼进行检查。通过在吲哚菁绿视频血管造影获得的图像中使用数字化仪测量新生血管膜的面积。
7只易患期眼的房水闪光平均值为5.91±2.51（光子计数/毫秒），15只初期眼为5.68±1.64，24只晚期眼为9.09±7.65，11只盘状瘢痕眼为5.40±1.42，29只对侧眼为5.36±1.72。SDMD晚期眼的房水闪光值显著高于对侧眼（P<0.01）。易患期、初期和盘状瘢痕眼与对侧眼之间的房水闪光值无显著差异。房水闪光值随新生血管膜面积的增加而显著增加（R=0.68，P<0.01）。
目前的结果表明，SDMD患者眼中房水闪光随新生血管膜面积的增加而增加，随新生血管膜的瘢痕化而降低。
