DNA疫苗。
DNA vaccine.
作者信息
Cui Zhengrong
机构信息
Department of Pharmaceutical Sciences, College of Pharmacy Oregon State University, Corvallis, Oregon 97331, USA.
出版信息
Adv Genet. 2005;54:257-89. doi: 10.1016/S0065-2660(05)54011-2.
Abstract
The DNA vaccine has proven to be one of the most promising applications in the field of gene therapy. Due to its unique ability to readily induce humoral as well as cellular immune responses, it attracted great interest when the concept was first confirmed in the early 1990s. After thousands of articles related to the DNA vaccine were published, scientists began to realize that although the DNA vaccine is very effective in small animal models, its effectiveness in recent clinical trails is rather disappointing. Therefore, current effort has been shifted to understanding the different performance of the DNA vaccine in mouse and large animal models and on how to transfer the success of the DNA vaccine in small animals to large animals and humans.
摘要
DNA疫苗已被证明是基因治疗领域最具前景的应用之一。由于其具有易于诱导体液免疫和细胞免疫反应的独特能力，自20世纪90年代初该概念首次得到证实以来，它就引起了极大的关注。在发表了数千篇与DNA疫苗相关的文章之后，科学家们开始意识到，尽管DNA疫苗在小动物模型中非常有效，但其在最近的临床试验中的效果却相当令人失望。因此，目前的工作重点已转向了解DNA疫苗在小鼠和大型动物模型中的不同表现，以及如何将DNA疫苗在小动物中的成功应用推广到大型动物和人类身上。
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