咖啡酸苯乙酯（CAPE）对大鼠心肌缺血/再灌注损伤的抗心律失常作用
Antiarrhythmic effect of caffeic acid phenethyl ester (CAPE) on myocardial ischemia/reperfusion injury in rats.
作者信息
Huang Shiang-Suo, Liu Sheng-Ming, Lin Su-Man, Liao Pei-Hu, Lin Ruey-Hseng, Chen Yu-Chia, Chih Chun-Lien, Tsai Shen-Kou
机构信息
Department of Pharmacology and Institute of Medicine, College of Medicine, Chung Shan Medical University, Taichung, Taiwan.
出版信息
Clin Biochem. 2005 Oct;38(10):943-7. doi: 10.1016/j.clinbiochem.2005.07.003.
OBJECTIVES
The present study was designed to determine the antiarrhythmic effect of caffeic acid phenethyl ester (CAPE), an active component of propolis, which exhibits antioxidant properties, in rats subjected to myocardial ischemia and ischemia-reperfusion (I/R) injury.
DESIGN AND METHODS
Rats were subjected to 30 min coronary artery occlusion for evaluating the effect of CAPE on the myocardial ischemia injury. While in the myocardial I/R injury study, the coronary artery was ligated for a 5-min period of ischemia followed by a 30-min period of reperfusion. Animals were pretreated with or without CAPE before coronary artery ligation and the severity of myocardial ischemia- and I/R-induced arrhythmias and mortality were compared.
RESULTS
Pretreatment of CAPE (0.1 and 1 microg/kg) not only reduced both the incidence and duration of ventricular tachycardia (VT) and ventricular fibrillation (VF) but also decreased the mortality during the myocardial ischemia and I/R injury period.
CONCLUSIONS
Our results suggest that CAPE is a potent antiarrhythmic agent with cardioprotective effects in myocardial ischemia and I/R injury rats.
目的
本研究旨在确定蜂胶的活性成分咖啡酸苯乙酯（CAPE）在经历心肌缺血和缺血再灌注（I/R）损伤的大鼠中的抗心律失常作用，该成分具有抗氧化特性。
设计与方法
对大鼠进行30分钟冠状动脉闭塞，以评估CAPE对心肌缺血损伤的作用。在心肌I/R损伤研究中，冠状动脉结扎5分钟造成缺血，随后再灌注30分钟。在冠状动脉结扎前，对动物进行或不进行CAPE预处理，并比较心肌缺血和I/R诱导的心律失常的严重程度以及死亡率。
结果
CAPE（0.1和1微克/千克）预处理不仅降低了室性心动过速（VT）和室性颤动（VF）的发生率和持续时间，还降低了心肌缺血和I/R损伤期间的死亡率。
结论
我们的结果表明，CAPE是一种有效的抗心律失常药物，对心肌缺血和I/R损伤大鼠具有心脏保护作用。
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