Davis Jerel C, Petrov Dmitri A
Department of Biological Sciences, Stanford University, 371 Serra Mall, Stanford, CA 90305-5020, USA.
Trends Genet. 2005 Oct;21(10):548-51. doi: 10.1016/j.tig.2005.07.008.
Gene duplication is the fundamental source of new genes. Biases in duplication have profound implications for the dynamics of gene content during evolution. In this article, we compare genes arising from whole gene duplication (WGD), smaller scale duplication (SSD) and singletons in Saccharomyces cerevisiae. Our results demonstrate that genes duplicated by WGD and SSD are similarly biased with respect to codon bias and evolutionary rate, although differing significantly in their functional constituency.
基因复制是新基因的基本来源。复制过程中的偏差对进化过程中基因含量的动态变化有着深远影响。在本文中，我们比较了酿酒酵母中全基因组复制（WGD）、小规模复制（SSD）以及单拷贝基因产生的基因。我们的结果表明，尽管WGD和SSD复制产生的基因在功能组成上有显著差异，但在密码子偏好和进化速率方面具有相似的偏差。
