哺乳动物紧密连接在上皮细胞分化和增殖调控中的作用

Mammalian tight junctions in the regulation of epithelial differentiation and proliferation.

作者信息

Matter Karl, Aijaz Saima, Tsapara Anna, Balda Maria S

机构信息

Division of Cell Biology, Institute of Ophthalmology, University College London, Bath Street, London, EC1V 9EL, UK.

出版信息

Curr Opin Cell Biol. 2005 Oct;17(5):453-8. doi: 10.1016/j.ceb.2005.08.003.

DOI:10.1016/j.ceb.2005.08.003

PMID:16098725

Abstract

Tight junctions are important for the permeability properties of epithelial and endothelial barriers as they restrict diffusion along the paracellular space. Recent observations have revealed that tight junctions also function in the regulation of epithelial proliferation and differentiation. They harbour evolutionarily conserved protein complexes that regulate polarisation and junction assembly. Tight junctions also recruit signalling proteins that participate in the regulation of cell proliferation and differentiation. These signalling proteins include components that affect established signalling cascades and dual localisation proteins that can associate with junctions as well as travel to the nucleus where they regulate gene expression.

摘要

紧密连接对于上皮和内皮屏障的通透性特性很重要，因为它们限制了沿细胞旁间隙的扩散。最近的观察表明，紧密连接在调节上皮细胞增殖和分化中也发挥作用。它们含有进化上保守的蛋白质复合物，这些复合物调节极化和连接组装。紧密连接还招募参与细胞增殖和分化调节的信号蛋白。这些信号蛋白包括影响既定信号级联反应的成分以及可与连接相关并进入细胞核调节基因表达的双定位蛋白。