Haraldsson A, Weemaes C M, Kock-Jansen M J, Van Eck-Arts P B, de Boo T, Bakkeren J A, Stoelinga G B
Department of Paediatrics, University Hospital Nijmegen, The Netherlands.
Ann Clin Biochem. 1992 May;29 ( Pt 3):271-4. doi: 10.1177/000456329202900303.
Values for the kappa/lambda light chain ratio in immunoglobulins G, A and M and the total kappa/lambda ratio, measured by enzyme linked immunosorbent assay, were evaluated in serum samples from different age groups (114 children, aged from 1 month to 15 years, and 20 adults). The IgG kappa/lambda ratio decreased in the first 6 months and subsequently increased slowly during childhood towards the adult value of 2.0. The IgM kappa/lambda ratio increased at a greater rate than IgG kappa/lambda ratio in the first years of life and thereafter rose slightly throughout childhood to reach an adult value of 1.7. A decreasing IgA kappa/lambda ratio was found from 1 month of age onwards to an adult value of 1.1. The pattern of total kappa/lambda ratio was similar to the IgG kappa/lambda ratio with an adult value of 2.0.
