Haraldsson A, de Vaan G A, van Dijk W J, Bakkeren J A, Weemaes C M
Department of Pediatrics, University Hospital Nijmegen, The Netherlands.
Pediatr Hematol Oncol. 1994 Jan-Feb;11(1):83-90. doi: 10.3109/08880019409141904.
The light chain ratios and the concentrations of immunoglobulin G (IgG), IgA, and IgM were measured before, during, and after antileukemic therapy in 10 patients with common acute lymphoblastic leukemia. The concentrations of IgG, IgA, and IgM decreased substantially during treatment but recovered slowly after cessation of the therapy. The light chain ratios were not systematically affected, but at diagnosis the kappa/lambda ratios of total serum Igs, IgG, and in particular IgM were somewhat lower in the patient group compared with an age-matched reference group. It is concluded that, despite a decrease in serum Ig concentrations, virtually normal kappa/lambda ratios are preserved, indicating that kappa and lambda syntheses are affected to the same extent. These ratios remained normal for age during the recovery of the serum Ig concentrations; the features as described for the development of the light chain ratios in childhood were not observed.
对10例普通急性淋巴细胞白血病患者在抗白血病治疗前、治疗期间及治疗后测定了轻链比例以及免疫球蛋白G（IgG）、IgA和IgM的浓度。治疗期间IgG、IgA和IgM的浓度大幅下降，但治疗停止后恢复缓慢。轻链比例未受到系统性影响，但在诊断时，与年龄匹配的参照组相比，患者组中总血清免疫球蛋白、IgG尤其是IgM的κ/λ比例略低。得出的结论是，尽管血清免疫球蛋白浓度下降，但κ/λ比例实际上保持正常，表明κ和λ合成受到的影响程度相同。在血清免疫球蛋白浓度恢复期间，这些比例按年龄保持正常；未观察到儿童期轻链比例发展过程中所描述的特征。
