Li Fenfang, Park Sarah Y, Ayers Tracy L, Miller F DeWolfe, MacFadden Ralph, Nakata Michele, Lee Myra Ching, Effler Paul V
University of Hawaii School of Medicine, Honolulu, Hawaii, USA.
Emerg Infect Dis. 2005 Aug;11(8):1205-10. doi: 10.3201/eid1108.050164.
The emergence of methicillin-resistant Staphylococcus aureus (MRSA) has generated considerable concern among medical and public health professionals. We used a statewide, population-based antimicrobial resistance surveillance system to examine epidemiologic trends for MRSA from outpatients and inpatients in Hawaii. Pediatric and adult patient populations were compared to assess characteristics of MRSA isolates specific for each group. From 2000 to 2002, 8,206 (26%) of 31,482 total S. aureus isolates were MRSA. During this period, the proportion of MRSA isolates increased in both outpatient and inpatient clinical settings (p<0.01). When stratified by age, annual trends showed a significant increase in the proportion of MRSA in adult patients (from 24% to 30%, p<0.01) but not in pediatric patients (from 25% to 27%, p>0.05). Although MRSA isolates from adults demonstrated high resistance to most non-beta-lactams, most MRSA isolates from pediatric outpatients remained susceptible to most non-beta-lactams.
耐甲氧西林金黄色葡萄球菌（MRSA）的出现引起了医学和公共卫生专业人员的广泛关注。我们利用一个基于全州人口的抗菌药物耐药性监测系统，研究了夏威夷门诊和住院患者中MRSA的流行病学趋势。对儿科和成人患者群体进行了比较，以评估每组特有的MRSA分离株的特征。2000年至2002年期间，在总共31482株金黄色葡萄球菌分离株中，有8206株（26%）为MRSA。在此期间，门诊和住院临床环境中MRSA分离株的比例均有所增加（p<0.01）。按年龄分层时，年度趋势显示成人患者中MRSA的比例显著增加（从24%增至30%，p<0.01），而儿科患者中则未出现显著增加（从25%增至27%，p>0.05）。虽然成人的MRSA分离株对大多数非β-内酰胺类药物表现出高度耐药性，但大多数儿科门诊患者的MRSA分离株对大多数非β-内酰胺类药物仍敏感。
