幽门螺杆菌感染的生物学特性，胃腺癌的主要危险因素。
The biology of Helicobacter pylori infection, a major risk factor for gastric adenocarcinoma.
作者信息
Pinto-Santini Delia, Salama Nina R
机构信息
Human Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3-168, PO Box 19024, Seattle, WA 98109-1024, USA.
出版信息
Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1853-8. doi: 10.1158/1055-9965.EPI-04-0784.
Helicobacter pylori infection of the human stomach is the most important risk factor for development of gastric cancer. Whereas persistent viral infection leads to a number of cancers, H. pylori was the first bacteria linked to a human cancer. The exact mechanisms that lead to cancer induction are not clear, but study of the bacterial factors important for colonization and the host responses to the infection are starting to yield important clues.
幽门螺杆菌感染人类胃部是胃癌发生的最重要风险因素。虽然持续性病毒感染会引发多种癌症，但幽门螺杆菌是第一种与人类癌症相关的细菌。导致癌症诱发的确切机制尚不清楚，但对细菌定植重要因素以及宿主对感染反应的研究开始产生重要线索。
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