Segond P, Delfraissy J F, Galanaud P, Dormont J, Massias P
Rev Rhum Mal Osteoartic. 1979 Dec;46(12):697-704.
We have studied the in vitro antibody response to a hapten of peripheral blood lymphocytes from 26 patients with rheumatoid arthritis and 7 ankylosing spondylitis. These patients had never received immunosuppressor drugs before or corticosteroids during the month before the test. They had failed to receive aspirin or non-steroid anti-inflammatory drugs for 72 hours before blood sampling. The control groups included respectively 38 healthy subjects and 24 patients hospitalized for non inflammatory disease. The antibody response of ankylosing spondylitis patients is comparable to that of controls ; on the opposite the response of patients with rhumatoid arthritis is significantly depressed in comparison with the three other groups. The weak response of lymphocytes in arthritis is not due to increased cell death in culture or to modified kinetics of the antibody response or to the appearance of a IgG secondary type response or a in vivo pre-activation. The lymphocytes of arthritis patients do not inhibit the response of normal lymphocytes when they are co-cultured. The observed response is identical to that obtained when control patient lymphocytes are co-cultured with normal lymphocytes. The function of suppressor T cells induced by Con A seems normal in spondylitis and arthritis.
我们研究了26例类风湿性关节炎患者和7例强直性脊柱炎患者外周血淋巴细胞对半抗原的体外抗体反应。这些患者在测试前一个月从未接受过免疫抑制剂药物或皮质类固醇治疗。在采血前72小时内，他们未服用过阿司匹林或非甾体抗炎药。对照组分别包括38名健康受试者和24名因非炎症性疾病住院的患者。强直性脊柱炎患者的抗体反应与对照组相当；相反，类风湿性关节炎患者的反应与其他三组相比明显降低。关节炎患者淋巴细胞反应较弱并非由于培养中细胞死亡增加、抗体反应动力学改变、IgG二型反应出现或体内预激活。关节炎患者的淋巴细胞与正常淋巴细胞共培养时，不会抑制正常淋巴细胞的反应。观察到的反应与对照患者淋巴细胞与正常淋巴细胞共培养时获得的反应相同。由刀豆球蛋白A诱导的抑制性T细胞功能在脊柱炎和关节炎中似乎正常。
