Chattopadhyay C, Chattopadhyay H, Natvig J B, Michaelsen T E, Mellbye O J
Scand J Immunol. 1979;10(4):309-16. doi: 10.1111/j.1365-3083.1979.tb01356.x.
Lymphocytes were eluted from the synovial tissue of seventeen patients with rheumatoid arthritis (RA) and one with ankylosing spondylitis. In eight of these patients immunoglobulin production by synovial lymphocytes in the presence and absence of pokeweed mitogen was studied. In nine patients T lymphocytes were isolated from the eluted cells, and the T helper and suppressor cell functions were evaluated in an allogeneic co-culture system. Peripheral blood lymphocytes (PBL) from twenty-eight normal donors were also studied for comparison. Immunoglobulin produced by synovial lymphocytes was higher than in PBL of normal donors. However, the stimulation index of synovial tissue lymphocytes was lower. Most of the normal donors had suppressor cell activity in their peripheral blood, whereas in synovial tissue lymphocytes a statistically significant number of patients did not have any suppressor cell activity. In contrast, the synovial tissue lymphocytes showed helper activity not differing significantly from that of the T lymphocytes from peripheral blood of normal individuals.
从17例类风湿性关节炎（RA）患者和1例强直性脊柱炎患者的滑膜组织中洗脱淋巴细胞。在其中8例患者中，研究了有无商陆有丝分裂原情况下滑膜淋巴细胞的免疫球蛋白产生情况。在9例患者中，从洗脱细胞中分离出T淋巴细胞，并在同种异体共培养系统中评估T辅助细胞和抑制细胞功能。还研究了28名正常供体的外周血淋巴细胞（PBL）作为对照。滑膜淋巴细胞产生的免疫球蛋白高于正常供体的外周血淋巴细胞。然而，滑膜组织淋巴细胞的刺激指数较低。大多数正常供体的外周血中有抑制细胞活性，而在滑膜组织淋巴细胞中，有统计学意义的一部分患者没有任何抑制细胞活性。相反，滑膜组织淋巴细胞显示出的辅助活性与正常个体外周血T淋巴细胞的辅助活性没有显著差异。
