Efstathiou Stamatis P, Tsioulos Dimitrios I, Tsiakou Aphrodite G, Gratsias Yannis E, Pefanis Angelos V, Mountokalakis Theodore D
Center for the Prevention of Cardiovascular Disease, Hygieias Melathron, Athens, Greece.
Stroke. 2005 Sep;36(9):1915-9. doi: 10.1161/01.STR.0000177874.29849.f0. Epub 2005 Aug 18.
This study aimed to investigate the association between plasma adiponectin levels and 5-year survival after first-ever ischemic stroke.
Plasma adiponectin measured within 24 hours after first-ever ischemic stroke was related to 5-year outcome. The Kaplan-Meier technique was applied in survival analysis, and the Cox proportional hazards model was used to evaluate the relationship between risk factors and prognosis.
The probabilities of death were 92.8%, 52.5%, and 10.5% (P<0.001) for patients stratified according to tertiles of adiponectin (<4 microg/mL, 4 to 7 microg/mL, and >7 microg/mL, respectively). The relative risk of death was 8.1 (95% CI, 3.1, 24.5; P<0.001) for individuals with adiponectin levels in the lowest tertile compared with the upper tertile. Adiponectin <4 microg/mL (hazard ratio [HR], 5.2; 95% CI, 2.1, 18.4; P<0.001), score >15 in the National Institutes of Health Stroke Scale (HR, 3.6; 95% CI, 1.7, 15.9; P<0.001), and coronary heart disease (HR, 2.9; 95% CI, 1.5, 12.3; P<0.001) were independently associated with mortality.
Low plasma adiponectin is related to an increased risk of 5-year mortality after first-ever ischemic stroke, independently of other adverse predictors.
本研究旨在探讨首次缺血性卒中后血浆脂联素水平与5年生存率之间的关联。
首次缺血性卒中后24小时内测得的血浆脂联素与5年预后相关。生存分析采用Kaplan-Meier技术，Cox比例风险模型用于评估危险因素与预后之间的关系。
根据脂联素三分位数分层的患者（分别为<4微克/毫升、4至7微克/毫升和>7微克/毫升）的死亡概率分别为92.8%、52.5%和10.5%（P<0.001）。与最高三分位数相比，脂联素水平处于最低三分位数的个体的相对死亡风险为8.1（95%CI，3.1，24.5；P<0.001）。脂联素<4微克/毫升（风险比[HR]，5.2；95%CI，2.1，18.4；P<0.001）、美国国立卫生研究院卒中量表评分>15（HR，3.6；95%CI，1.7，15.9；P<0.001）和冠心病（HR，2.9；95%CI，1.5，12.3；P<0.001）与死亡率独立相关。
首次缺血性卒中后，低血浆脂联素与5年死亡风险增加相关，独立于其他不良预测因素。
