Tomazett Patrícia Kott, Cruz Aline Helena da Silva, Bonfim Sheyla Maria Rondon Caixeta, Soares Célia Maria de Almeida, Pereira Maristela
Laboratório de Biologia Molecular, Universidade Federal de Goiás, 74001-970 Goiânia, GO, Brazil.
Genet Mol Res. 2005 Jun 30;4(2):309-25.
The cell wall of a human pathogenic fungus is in contact with the host, serves as a barrier against host defense mechanisms and harbors most fungal antigens. In addition, cell wall biosynthesis pathways have been recognized as essential to viability and as specific drug targets. Paracoccidioides brasiliensis is a dimorphic fungus that presents mycelium morphology in the free environment and causes infection in a yeast form. The morphogenetic conversion is correlated with changes in the cell wall composition, organization and structure. Based on transcriptome analysis, the enzymes involved in the biosynthesis and remodeling of cell wall polysaccharides, as well as several cell wall-associated molecules of P. brasiliensis, were identified and addressed in further detail.
人类致病真菌的细胞壁与宿主接触，作为抵御宿主防御机制的屏障，并含有大多数真菌抗原。此外，细胞壁生物合成途径已被认为对真菌的生存至关重要，并且是特定的药物靶点。巴西副球孢子菌是一种双态真菌，在自由环境中呈现菌丝体形态，并以酵母形式引起感染。形态发生转变与细胞壁组成、组织和结构的变化相关。基于转录组分析，鉴定并更详细地研究了参与细胞壁多糖生物合成和重塑的酶，以及巴西副球孢子菌的几种细胞壁相关分子。
