Rom-Bugoslavskaja E S, Bondarenko L
Endocrinology and Hormone Chemistry Research Institute, Kharkov, USSR.
Acta Physiol Hung. 1987;70(4):397-401.
In intact Wistar pubertal male rats held on LD 8:16 (winter) and 16:8 (summer) pineal melatonin (M) production and other pineal indoles content serotonin (S), 5-methoxytriptamine (5-MT), N-acetylserotonin (N-aS), 5-hydroxyindoleacetic acid (5-HIAA) and 5-methoxyindoleacetic acid (5-MIAA) were investigated in basic conditions and after 10-days T4 administration. The results suggest, that intact control in winter comparing with summer demonstrates high M, N-aS, 5-HIAA and 5-MIAA level, but low 5-MT concentrations, S level was not changed. T4 administration in winter produced a pronounced augmentation of all parameters (excluding serotonin), in summer M production not only increased, but appears to be dependent on the active metabolism of his precursors (S, 5-MT, N-aS). The experimental data favour more profound comprehension to the mechanisms of pineal activity regulation.
在处于8:16光照-黑暗周期（冬季）和16:8光照-黑暗周期（夏季）的完整Wistar青春期雄性大鼠中，研究了基础条件下以及给予甲状腺素（T4）10天后松果体褪黑素（M）的分泌以及其他松果体吲哚类物质的含量，包括血清素（S）、5-甲氧基色胺（5-MT）、N-乙酰血清素（N-aS）、5-羟基吲哚乙酸（5-HIAA）和5-甲氧基吲哚乙酸（5-MIAA）。结果表明，与夏季相比，处于冬季的完整对照大鼠表现出较高的M、N-aS、5-HIAA和5-MIAA水平，但5-MT浓度较低，S水平未发生变化。冬季给予T4导致所有参数（血清素除外）显著增加，夏季给予T4后，M的分泌不仅增加，而且似乎依赖于其前体（S、5-MT、N-aS）的活跃代谢。实验数据有助于更深入地理解松果体活动调节机制。
